Abstract
Recombinational interactions between homologous chromosomes are important in meiosis and are generally considered relevant to chromosomal segregation. In mitotic cells sister chromatid recombination is a common response to DNA damage and it appears to have repair function. Using the model eukaryote Saccharomyces cerevisiae, we have pursued the role and mechanisms of recombination in repair, meiotic development and chromosome segregation or stability (Resnick, 1987; Nilsson-Tillgren et al., 1986; Kielland-Brandt et al., 1983). This yeast provides an opportunity to examine these processes in synchronized mitotic and meiotic cells, identify mutants, obtain relevant proteins as well as understand the relationship between mitotic and meiotic functions.
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© 1990 Springer Science+Business Media New York
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Resnick, M.A., Nilsson-Tillgren, T. (1990). DNA Repair and the Recombination Barrier Between Divergent (Homologous) Chromosomes. In: Kappas, A. (eds) Mechanisms of Environmental Mutagenesis-Carcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3808-0_5
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DOI: https://doi.org/10.1007/978-1-4615-3808-0_5
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