Abstract
Congenital anomalies (CA) are believed to be one of the best mutation endpoints for the genetic monitoring in regions polluted by environmental mutagens (Crow, 1971). It is well known they are heterogenous by their etiology. Their fluctuation in time may correspond to the changing concentration of mutagens. The determination of CA should be based on medical-statistical data. But it may be possible only in the case of detailed identification of each CA in the proband and detailed analysis of other additional data (Czeizel and Sankaranarayanan, 1984; Bochkov and Sram, 1989).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bochkov, N.P., and Sram, R.J., 1989, Modem trends and realities of genetic monitoring, Biol. Znet. bl., 108:341.
Cerna, M., Hajek, V., Stejskalova, E., Dobias, L., and Zudova, Z., 1987, Chemical contaminants in water and their possible late effects. II Practical experience with examination of the mutagenic activity of drinking water, (in Czech), Cs. Hyg. 32:355.
Crow, J.F., 1971, Human population monitoring, in: “Chemical Mutagens. Principles and Methods for their Detection”, Vol. 2, A. Hollaender, ed., Plenum Press, New York.
Czeizel, A., and Sankaranarayaman, K., 1984, The lcad of genetic and partially genetic disorders in man. I. Congenital anomalies: estimates of detriment in terms of years of life last and years of impaired life, Mutation Res., 128:73.
Dixon, W.J., (1985), BMDP Statistical Software, Printing, University of California, Berkeley, CA.
Jagiello, G.M., Liu, J.S., and Ducayeu, M.B., 1975, SO2 and its metabolite: Effects on mammalian egg chromosomes, Environ. Res., 9:84.
Myrianthopulos, N..G., and Chung, C.S., 1974, Congenital malformations in singletons: Epidemiological survey, birth defects, original Article Series, The National Formation March of Dimes, 10:1.
Sram, R.J., Kopacilova, G., Bartova, J., Roth, Z., and Seemanova, E., 1974, Delivery records analysis as an approach to determine possible effect of environmental pollution to the pollution genetic load (in Czech), Cs. Hyq., 19:426.
World Health Organization, 1977, International Classification of Diseases. Manual of the International Statistical Classification of Diseases, Injuries and Causes of Death, Vol. 1 and 2, WHO, Geneva.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer Science+Business Media New York
About this chapter
Cite this chapter
Sram, R.J., Roznickova, I., Albrecht, V., Berankova, A., Machovska, E. (1990). Monitoring Congenital Anomalies in Populations Exposed to Environmental Mutagens. In: Kappas, A. (eds) Mechanisms of Environmental Mutagenesis-Carcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3808-0_21
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3808-0_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6698-0
Online ISBN: 978-1-4615-3808-0
eBook Packages: Springer Book Archive