Nitroarenes pp 157-166 | Cite as

Comparison of the Mutagenic Potency of DNA Adducts Formed by Reactive Derivatives of Aflatoxin, Benzidine and 1-Nitropyrene in a Plasmid System

  • Carl N. Martin
  • Gary S. Jennings
Part of the Environmental Science Research book series (ESRH, volume 40)


1-Nitropyrene is an ubiquitous environmental pollutant which has been detected in the urban atmosphere in many areas of the world (1). It is generated primarily by incomplete combustion of fossil fuels and thus is present in relatively high concentrations in emissions such as diesel engine exhaust fumes (2, 3) and power station fly-ash (4, 5). This compound has been shown to be biologically active in a number of in vitro genotoxicity assay systems, inducing mutation in Salmonella typhimurium (6) and inducing mutations, unscheduled DNA synthesis, transformation or chromosomal rearrangements in a variety of mammalian cell lines (7–10). 1-nitropyrene has also been shown to be carcinogenic in laboratory animals (11, 12). The activation of 1-nitropyrene has been shown to involve a sequential two-electron reduction leading to the formation of 1-NOP, N-OH-l-aminopyrene and 1-aminopyrene (13, 14). The N-hydroxy derivative has been shown to be an ultimate DNA-reactive species (13). The adduct produced in DNA by the reactive metabolite of 1-nitropyrene has been identified in bacterial systems (15) and in rat liver (16) as N-(deoxyguanosin-8-yl)-1-aminopyrene. Thus, 1-nitropyrene is a compound to which the human population is exposed and is biologically active in a number of experimental systems. However, very little information is available as to the relative carcinogenic risk to humans chronically exposed to this compound.


Plasmid System Diesel Engine Exhaust Caesium Chloride Mutagenic Potency Mouse Lymphoma L1578Y 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Carl N. Martin
    • 1
  • Gary S. Jennings
    • 1
  1. 1.Cancer Research UnitUniversity of YorkYorkEngland

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