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Cytoskeletal Organization of Normal and Leukemic Lymphocytes and Lymphoblasts

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Blood Cell Biochemistry Volume 3

Part of the book series: Blood Cell Biochemistry ((BLBI,volume 3))

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Abstract

The cytoskeleton of eukaryotic cells is a complex array composed of three sets of filaments: (1) microfilaments, 4 to 7 nm in diameter, made up mainly of actin; (2) intermediate filaments, 8 to 11 nm in diameter, formed by at least five distinct classes of proteins; and (3) microtubules, 25 nm in diameter, consisting of tubulin (for review, see Alberts et al., 1983). Many proteins have been described that interconnect these filaments or link them to various organelles. The cytoskeleton is involved in many basic cellular functions, including maintenance of cell shape, motility, organelle movement, and mitosis. Studies of cytoskeletal protein expression and organization have increased our understanding of the cellular adaptation during differentiation and pathological processes (for a review, see Rungger-Brändle and Gabbiani, 1983).

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Authors and Affiliations

  1. Department of Pathology, University of Geneva, Geneva, Switzerland

    Annette Schmitt-Gräff & Giulio Gabbiani

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  1. Annette Schmitt-Gräff
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  2. Giulio Gabbiani
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  1. North East Thames Regional Transfusion Centre, Brentwood, Essex, England

    J. R. Harris

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Schmitt-Gräff, A., Gabbiani, G. (1991). Cytoskeletal Organization of Normal and Leukemic Lymphocytes and Lymphoblasts. In: Harris, J.R. (eds) Blood Cell Biochemistry Volume 3. Blood Cell Biochemistry, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3796-0_3

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  • DOI: https://doi.org/10.1007/978-1-4615-3796-0_3

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