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Blood Cell Biochemistry Volume 3 pp 33–71Cite as

Cell Surface Markers in Leukemia and Lymphoma

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Part of the book series: Blood Cell Biochemistry ((BLBI,volume 3))

Abstract

The hematologic malignancies have long been recognized to be both morphologically and clinically heterogeneous. In the past decade, there have been significant advances in the identification and characterization of the cell surface molecules that are expressed on normal lymphoid and myeloid cells. The application of these markers to the study of leukemias and lymphomas has initiated an understanding of the heterogeneity and both the biologic and clinical behavior of these tumors. It is now possible to assign a lineage derivation to a neoplastic hematopoietic cell in virtually all cases by the expression of lineage-restricted antigens (Ags). More importantly, by using markers that define stages of normal T, B, and myeloid differentiation, it is possible to begin to identify subsets of patients within histologically defined subgroups of leukemias and lymphomas that demonstrate unique clinical presentations, disease courses, and responses to therapy.

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Authors and Affiliations

  1. Division of Tumor Immunology, Dana-Farber Cancer Institute and the Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Arnold S. Freedman

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  1. Arnold S. Freedman
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  1. North East Thames Regional Transfusion Centre, Brentwood, Essex, England

    J. R. Harris

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© 1991 Springer Science+Business Media New York

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Freedman, A.S. (1991). Cell Surface Markers in Leukemia and Lymphoma. In: Harris, J.R. (eds) Blood Cell Biochemistry Volume 3. Blood Cell Biochemistry, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3796-0_2

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  • DOI: https://doi.org/10.1007/978-1-4615-3796-0_2

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