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Cell Biology of Extracellular Matrix pp 221–254Cite as

Matrix Assembly

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Abstract

Matrix assembly, disassembly, and reassembly of collagenous matrices are dynamic processes which occur when an organism undergoes morphogenesis, growth, repair, or regeneration. They are complex events which ascend the biological hierarchy from molecular interactions among adjacent molecules to macroscopic interactions among adjacent tissues. The multiple levels of organization involved in matrix assembly from molecules to final structure, while not understood, can be appreciated by consideration of your hand: over 90% of the organic matter in the skin, tendons, ligaments, and bones is type I collagen. The genetic and chemical details of type I collagen are relatively well understood and discussed in detail in other chapters; however, the assembly algorithms which partition and position these molecules in three-dimensional space into a functional grasping and holding device are not. In vitro studies of isolated type I collagen and procollagen have indicated that much of the assembly process of a collagen fibril can be explained by physicochemical forces, often described as “self-assembly.” Light microscopic studies of type I collagen-rich tissues reveal a variety of architectures ranging from near-complete molecular alignment in tendons and ligaments; a tight, orthogonal network in bone; and a loose network arrangement in skin (Fig. 7-1). Ultrastructural studies of cells producing type I collagen indicate that fibrils form in association with the cell’s external surface in a complex topographic relationship and that the initial elements formed by the cells are relatively short, discontinuous fibril segments. The relationships of the cell-defined extra-cellular domains with matrix assembly permit cellular regulation of the self-assembly process by the manipulation of the microenvironment and temporal and spatial regulation by determination of the time and place of matrix deposition.

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Authors and Affiliations

  1. Department of Pathology, Robert Wood Johnson Medical School, Piscataway, New Jersey, 08854, USA

    David E. Birk, Frederick H. Silver & Robert L. Trelstad

Authors
  1. David E. Birk
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  2. Frederick H. Silver
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  3. Robert L. Trelstad
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Editor information

Editors and Affiliations

  1. Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Elizabeth D. Hay

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© 1991 Springer Science+Business Media New York

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Birk, D.E., Silver, F.H., Trelstad, R.L. (1991). Matrix Assembly. In: Hay, E.D. (eds) Cell Biology of Extracellular Matrix. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3770-0_8

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  • DOI: https://doi.org/10.1007/978-1-4615-3770-0_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6680-5

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