Abstract
The anthracycline drugs are potent antitumour agents that have found a widespread use in cancer chemotherapy. Unfortunately their clinical use is limited by undesired side effects, of which cardiotoxicity is the most serious. In spite of 20 years of intensive research the action mechanism of these compounds in vivo still remains uncertain1. This is not due to a lack of known effects; on the contrary, the anthracyclines participate in a multitude of interactions with nucleic acids, enzymes, redox compounds and membranes. These interactions can all be studied and characterized in vitro, but in intact cell systems it is no longer possible to single out the various effects, and from the resulting bewilderment it has so far not been explainable where these antibiotics exert their function and why the side effects occur in other types of cells.
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Pedersen, J.Z., Rossi, L., Marcocci, L., Mavelli, I., Rotilio, G. (1990). Redox Activation of Drugs by the Red Blood Cell Membrane. In: Adams, G.E., Breccia, A., Fielden, E.M., Wardman, P. (eds) Selective Activation of Drugs by Redox Processes. NATO ASI Series, vol 198. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3768-7_8
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