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Redox Systems Generated by Electrochemical Oxidations and Reductions

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Selective Activation of Drugs by Redox Processes

Part of the book series: NATO ASI Series ((NSSA,volume 198))

Abstract

Electrochemical methods offer the possibility to carry out reduction and oxidation of numerous endogenic and exogenic biologically important compounds. The reduction and oxidation processes can involve both organic and inorganic species and can be carried out in nonaqueous media resembling situations in lipophilic systems or in aqueous media corresponding to situations in most biological fluids. Electrochemical methods enable studies of the effects of various cations and anions of electrolytes on the oxidation — reduction process. Electron transfers are often accompanied by proton transfers, particularly in hydroxylic solvents and effects of such transfers can be studied by following effects of pH in buffered solutions on electrochemical data. Electrochemical measurements can be carried out under conditions of no current flow, when potential of reversible oxidation-reduction systems can be measured. It should be stressed that Potentiometric measurements should be restricted to systems in which the equilibrium between the oxidized and reduced forms is rapidly established (which are denoted reversible) and fail when studies of irreversible systems (e.g. ascorbic acid or thiols) are attempted.

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Author information

Authors and Affiliations

  1. Department of Chemistry, Clarkson University, Potsdam, New York, 13676, USA

    Petr Zuman

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  1. Petr Zuman
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Editor information

Editors and Affiliations

  1. MRC Radiobiology Unit, Didcot, Chilton, Oxon., OX11 ORD, UK

    G. E. Adams  & E. M. Fielden  & 

  2. Facoltà di Farmacia, Istituto di Scienze Chimiche, Università Degli Studi di Bologna, 40127, Bologna, Via S. Donato, 15, Italy

    A. Breccia

  3. CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, HA6 2JR, UK

    P. Wardman

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Zuman, P. (1990). Redox Systems Generated by Electrochemical Oxidations and Reductions. In: Adams, G.E., Breccia, A., Fielden, E.M., Wardman, P. (eds) Selective Activation of Drugs by Redox Processes. NATO ASI Series, vol 198. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3768-7_4

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  • DOI: https://doi.org/10.1007/978-1-4615-3768-7_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6679-9

  • Online ISBN: 978-1-4615-3768-7

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