Molecular Interactions and Biological Effects of the Products of Reduction of Nitroimidazoles

  • Robert A. McClelland
Part of the NATO ASI Series book series (NSSA, volume 198)

Abstract

“Bioreductive drugs” exhibit selective toxicity towards hypoxic cells, a property of potential use in cancer therapy due to the presence of hypoxic regions in solid tumours. The model for the action of these drugs involves metabolic reduction, with some species produced by that reduction being biologically active. The selectivity arises since high concentrations of oxygen inhibit reduction, the one electron reduction product transferring its extra electron O2 and reverting back to parent drug1.

Keywords

Toxicity Adduct Oncol Thiol Aniline 

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Robert A. McClelland
    • 1
  1. 1.Department of ChemistryUniversity of TorontoTorontoCanada

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