Melatonin Action on Oncogenesis

Part of the NATO ASI Series book series (NSSA, volume 204)


Great strides have been made within the last decade in our understanding of the processes involved in oncogenesis not only at the organismal level but at the cellular-molecular level as well. It has become clear that hormones and growth factors play a prominent role in the mechanisms governing oncogenesis. The importance of the hormonal and growth factor regulation of oncogenesis is particularly evident with respect to cancer of the breasts1.


Human Breast Cancer Cell Mitogenic Effect Melatonin Receptor Breast Cancer Cell Growth Estrogen Receptor Level 
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  1. 1.
    M. E. Lippman and R. B. Dickson, Recent Prog. Horm. Res. 45:383 (1989).PubMedGoogle Scholar
  2. 2.
    D. E. Blask, The pineal: an oncostaticland?, in: “The Pineal Gland,” R. J. Reiter, ed., Raven Press, New York (1984).Google Scholar
  3. 3.
    D. E. Blask and S. M. Hill, Melatonin and cancer: basic and clinical aspects, in: “Melatonin: Clinical Perspectives,” A. Miles, C. Thompson and D. R. S. Philbrick, eds., Oxford Univ. Press, Oxford (1988).Google Scholar
  4. 4.
    D. E. Blask, The Emerging Role of the Pineal Gland and Melatonin in Oncogenesis, in: “Extremely Low Frequency Electro-magnetic Fields: The Question of Cancer,” B. W. Wilson, R. G. Stevens, L. E. Anderson, eds., Battelle Press, Columbus (1990).Google Scholar
  5. 5.
    D. E. Blask, S. M. Hill, D. B. Pelletier, J. M. Anderson and A. Lemus-Wilson, Melatonin: an anticancer hormone of the pineal gland, in: “Advances in Pineal Research,” Vol. 3, R.J. Reiter and S. F. Pang, eds., John Libbey & Co. Ltd., London (1989).Google Scholar
  6. 6.
    R. W. Ruddon, “Cancer Biology”, Oxford Univ. Press, Oxford (1987).Google Scholar
  7. 7.
    H. Wrba, F. Halberg and A. Dutter, Melatonin circadian-stage dependently delays breast tumor development in mice injected daily for several months, Chronobiol. 13:123 (1986).Google Scholar
  8. 8.
    H. Bartsch and C. Bartsch, Effect of melatonin on experimental tumours under different photoperiods and times of administration, J. Neural Transm. 52:269 (1981).PubMedCrossRefGoogle Scholar
  9. 9.
    R. J. Reiter, The pineal and its hormones in the control of reproduction in mammals, Endocr. Rev. 1:109 (1980).PubMedCrossRefGoogle Scholar
  10. 10.
    S. M. Hill and D. E. Blask, Effects of the pineal hormone, melatonin, on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture, Cancer Res. 48:6121 (1988).PubMedGoogle Scholar
  11. 11.
    B. Stankov, F. Scaglione and F. Fraschini, Specific binding in vitro and in vivo effects of melatonin on melanoma B16 and its metastatic growth, Prog. 16th Int’l Cong. Chemotherap. Abst. 234 (1989).Google Scholar
  12. 12.
    S. Cos and D. E. Blask, Effects of the pineal hormone melatonin on the anchorage-independent growth of human breast cancer cells (MCF-7) in a clonogenic culture system, Cancer Lett. 50:115 (1990).PubMedCrossRefGoogle Scholar
  13. 13.
    D. E. Blask and S. M. Hill, Effects of melatonin on cancer: studies on MCF-7 human breast cancer cells in culture, J. Neural Transm. Suppl. 21:433 (1986).PubMedGoogle Scholar
  14. 14.
    D. E. Blask, S. Cos, S. M. Hill, D. M. Burns, A. Lemus-Wilson, D. B. Pelletier, L. Liaw and A. Hill, Breast cancer: a target site for the oncostatic actions of pineal hormones, in: “Advances in Pineal Research,” Vol. 4, R. J. Reiter and A. Lukaszyk, eds., John Libbey & Co. Ltd, London (in press).Google Scholar
  15. 15.
    C. K. Osborne, D. H. Boldt and P. Estrada, Human breast cancer cell cycle synchronization by estrogens and anti-estrogens in culture, Cancer Res. 44:1433 (1984).PubMedGoogle Scholar
  16. 16.
    M. Saceda, M. E. Lippman, P. Chambon, R. L. Lindsey, M. Ponglikitmongkol, M. Puente and M. B. Martin, Regulation of the estrogen receptor in MCF-7 cells by estradiol, Mol. Endo. 2:1157 (1988).CrossRefGoogle Scholar
  17. 17.
    D. S. Grosso and B. R. Larsen, Estrogen sulfoconjugation by human endometrial cancer cells (RL95–2) in culture, Endocrinology 58:368 (1984).Google Scholar
  18. 18.
    C. K. Osborne and C. L. Artega, Autocrine and paracrine growth regulation of breast cancer: clinical implications, Breast Cancer Res. Treatment 15:3 (1990).CrossRefGoogle Scholar
  19. 19.
    R. Biswas and B. K. Vonderhaar, Role of serum in the prolactin responsiveness of MCF-7 human breast cancer cells during long term tissue culture, Cancer Res. 47:3509 (1987).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  1. 1.Departments of Anatomy and Obstetrics and GynecologyUniversity of Arizona College of MedicineTucsonUSA

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