Abstract
Proteoglycans are complex macromolecules which consist of a core glycoprotein backbone to which one or more glycosaminoglycan chains are attached through Oglycosidic linkages to serine residues. Glycosaminoglycans are unbranched chains of repeating disaccharide units in which one of the monosaccharides is an amino sugar and the other is invariably a hexuronic acid. Usually one type of glycosaminoglycan predominates on a single core protein giving rise to four main families: chondroitin sulfate proteoglycan (CS-PG), dermatan sulfate proteoglycan (DS-PG), heparan sulfate proteoglycan (HS-PG), and keratan sulfate proteoglycan (KS-PG) (1,2). An example of the basic structure of a typical proteoglycan is shown in Figure 1.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Berenson, G.S., Radhakrishnamurthy, B., Srinivasan, S.R., Vijayagopal, P., Dalferes, E.R., Jr. and Sharma, C. 1984. Recent advances in molecular pathology. Carbohydrate-protein macromolecules and arterial wall integrity-A role in atherogenesis. Exp. Mol. Pathol. 41: 267–287.
Camejo, G. 1982. The interaction of lipids and lipoproteins with the intercellular matrix of arterial tissue: Its possible role in atherogenesis. Adv. Lipid Res. 19: 1–53.
Castellot, J.J., Jr., Addonizio, M.L., Rosenberg, R., and Karnovsky, M.J. 1981. Cultured endothelial cells produce a heparinlike inhibitor of smooth muscle growth. J. Cell Biol. 90: 372–379.
Falcone, D.J., Hajjar, D.P. and Minick, C.R. 1980. Enhancement of cholesterol and cholesteryl ester accumulation in re-endothelialized aorta. Am. J. Pathol. 99: 81–104.
Falcone, D.J., Hajjar, D.P. and Minick, C.R. 1984. Lipoprotein and albumin accumulation in reendothelialized and deendothelialized aorta. Am. J. Pathol. 114: 112–120.
Fisher, L.W., Termine, J.D. and Young, M.F. 1989. Deduced protein sequences of bone small proteoglycan I (Biglycan) shows homology with proteoglycan II (Decorin) and several non-connective tissue proteins in a variety of species. J. Biol. Chem. 264: 4571–4576.
Garrigues, H.J., Lark, M.W., Lara, S., Hellstrom, I., Hellstrom, K.E. and Wight, T.N. 1986. The melanoma proteoglycan: restricted expression on microspikes. J. Cell Biol. 103: 1699–1710.
Hascall, V.C. and Hascall, G.K. 1981. Proteoglycans, in: Cell Biology of Extracellular Matrix, E.D. Hay, ed., Plenum Press, New York.
Hassel, J.R., Kimura, J.H. and Hascall, V.C. 1986. Proteoglycan core protein families. Annu. Rev. Biochem. 55: 539–567.
Jffrvâläinen, H., Kinsella, M.G., Sandell, L.J. and Wight, T.N. 1989. The small dermatan sulfate proteoglycan II (PG II) is expressed by bovine arterial smooth muscle cells but not by endothelial cells. J. Cell Biol. 109: 233a.
Kinsella, M.G. and Wight, T.N. 1986. Modulation of sulfated proteoglycan synthesis by bovine aortic endothelial cells during migration. J. Cell Biol. 102: 679–687.
Klinger, M.M., Margolis, R.U. and Margolis, R.K. 1985. Isolation and characterization of the heparan sulfate proteoglycans of brain. Use of affinity chromatography on lipoprotein lipase agarose. J. Biol. Chem. 260: 4082–4090.
Marcum, J.A., Reilly, C.F. and Rosenberg, R.D. 1987. Heparan sulfate species and blood vessel wall function, in: Biology of Extracellular Matrix: Biology of Proteoglycans, T.N. Wight and R.P. Mecham, eds., Academic Press, Orlando, FL.
McEvoy, L.M. and Bumol, T.F. 1988. Biosynthesis and localization of the core glycoprotein of chondroitin sulfate in primate aorta. J. Cell Biol. 107: 156a.
Richardson, M., Ihnatowycz, I. and Moore, S. 1980. Glycosaminoglycan distribution in rabbit aortic wall following balloon catheter deendothelialization. An ultrastructural study. Lab. Invest. 43: 509–516.
Schöenherr, E., Sandell, L.J. and Wight, T.N. 1989. Differential effect of PDGF and TGFB on proteoglycan and DNA synthesis by cultured arterial smooth muscle cells and chondrocytes. J. Cell Biol. 109: 234a.
Schöenherr, E., Sandell, L.J. and Wight, T.N. 1989. Differential effect of PDGF and TGFB on proteoglycan and DNA synthesis by cultured arterial smooth muscle cells and chondrocytes. J. Cell Biol. 109: 234a.
Tan, E.M.L., Levine, E., Sorger, P., Unger, G.A., Hacobian, N., Planick, B. and Iozzo, R.V. 1989. Heparin and endothelial cell growth factor modulate collagen and proteoglycan production in human smooth muscle cells. Biochem. Biophvs. Res. Comm. 163: 84–92.
Wight, T.N., Curwen, K.D., Litrenta, M.M., Alonso, D.R. and Minick, C.R. 1983. Effect of endothelium on glycosaminoglycan accumulation in injured rabbit aorta. Am. J. Pathol. 113: 156–164.
Wight, T.N., Potter-Perigo, S. and Aulinskas, T. 1989. Proteoglycans and vascular cell proliferation. Am. Rev. Reso. Dis. 140: 1132–1135.
Wight, T.N. 1988. Cell biology of arterial proteoglycans. Arteriosclerosis 1: 1–39.
Wight, T.N. 1980. Vessel proteoglycans and thrombogenesis, in: Progress in hemostasis and thrombosis, T.H. Spaet, ed., Grune and Stratton, New York.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Wight, T.N. (1991). Dynamic Interaction of Proteoglycans. In: Gotlieb, A.I., Langille, B.L., Fedoroff, S. (eds) Atherosclerosis. Altschul Symposia Series, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3754-0_9
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3754-0_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6672-0
Online ISBN: 978-1-4615-3754-0
eBook Packages: Springer Book Archive