Abstract
Endothelial cells (EC) have long been defined as a “passive” lining of vessels endowed with negative properties; the most important one being that of representing a non-thrombogenic substrate for blood. As such, EC were viewed to participate in tissue reactions essentially as target for injurious agents. The possibility to isolate and culture endothelial cells from various districts gave the tools for studying their complex reactions to a variety of activating stimuli. EC have, in this way, emerged as active participants in many physiological and pathological processes. It is now evident that hemostasis, inflammatory reactions, and immunity involve close interactions between immunocompetent cells and vascular endothelium. In particular, the ontogeny and function of white blood cells require an intimate relationship with vascular EC. Cytokines are mediators of these complex bidirectional interactions between leukocytes and vascular elements (for review see Mantovani and Dejana, 1989).
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Dejana, E., Bazzoni, G., Martin-Padura, I., Walter, S., Mantovani, A. (1991). Endothelial Cells as Targets for and Producers of Cytokines. In: Catravas, J.D., Callow, A.D., Gillis, C.N., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 208. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3736-6_7
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DOI: https://doi.org/10.1007/978-1-4615-3736-6_7
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