Autoantibodies to Endothelial Cells

  • Jeremy D. Pearson
Part of the NATO ASI Series book series (NSSA, volume 208)

Abstract

It has become apparent over the last 10 years that anti-endothelial cell antibodies (AECA) are present in a proportion of patients with a wide variety of autoimmune diseases that exhibit vascular pathology. These antibodies have, in general, been detected in one of two ways: by their ability to kill endothelial cells (EC) in vitro in the presence of complement or by their ability to bind to cultured EC monolayers and are therefore presumed to recognize antigens at the surface of EC.

Keywords

Interferon Integrin Thrombocytopenia Thrombin Vasculitis 

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Jeremy D. Pearson
    • 1
  1. 1.Section of Vascular BiologyMRC Clinical Research CentreMiddlesexUK

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