Abstract
The use of phthalocyanines as phototherapeutic agents for tumours was first proposed in 1985 (Ben-Hur and Rosenthal, 2985). A variety of cellular and animal studies, (for a review see Spikes, 1986;Tralau et al., 1987) have supported this proposal and it presently appears that some phthalocyanines are probable choices as second-generation tumour-localizers and -photosensitizers. At present, the phthalocyanines most frequently used in the experimental photodynamic therapy (PDT) of tumours include some sulfonated derivatives of the tetra-azaisoindole macrocycle (Brasseur et al., 1985;Ben-Hur and Rosenthal, 1986). Although these derivatives are relatively water-soluble, they are still a mixture of compounds with different degrees of sulfonation and/or showing structural isomerism.
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Jori, G., Biolo, R., Milanesi, C., Reddi, E., Valduga, G. (1991). Zinc(II)-Phthalocyanine as a Second-Generation Photosensitizing Agent in Tumour Phototherapy. In: Riklis, E. (eds) Photobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3732-8_91
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DOI: https://doi.org/10.1007/978-1-4615-3732-8_91
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