Zinc(II)-Phthalocyanine as a Second-Generation Photosensitizing Agent in Tumour Phototherapy
The use of phthalocyanines as phototherapeutic agents for tumours was first proposed in 1985 (Ben-Hur and Rosenthal, 2985). A variety of cellular and animal studies, (for a review see Spikes, 1986;Tralau et al., 1987) have supported this proposal and it presently appears that some phthalocyanines are probable choices as second-generation tumour-localizers and -photosensitizers. At present, the phthalocyanines most frequently used in the experimental photodynamic therapy (PDT) of tumours include some sulfonated derivatives of the tetra-azaisoindole macrocycle (Brasseur et al., 1985;Ben-Hur and Rosenthal, 1986). Although these derivatives are relatively water-soluble, they are still a mixture of compounds with different degrees of sulfonation and/or showing structural isomerism.
KeywordsZn(II)-phthalocyanine Photodynamic therapy Singlet oxygen Pharmacokinetics Ultrastructural studies
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- Jori, G., and Spikes, J.D. (1983). Photobiochemistry of porphyrins. In: Topics in Photomedicine (edited by K.C. Smith), Plenum Press, New York, pp..183–319.Google Scholar
- Ricchelli, F., Biolo, R., Reddi, E., Tognon, G., and Jori, G. (1988). Liposomes as carriers of hydrophobic photosensitizers in vivo : increased selectivity of tumour targeting. In: New Directions in Photodynamic Therapy (edited by D.C. Neckers), SPIE Publishers, Cambridge, Massachusetts, pp. 101–106.CrossRefGoogle Scholar
- Zhou, C., Yang, W.Z., Ding, Z.X., Wang, Y.X., Wang, H., Shen, H., Fang, X.J., and Ha, X.W. (1985). The biological effects of photodynamic therapy on normal skin in mice: an electron microscopic study. In: Methods in Porphyrin Photosensitization (edited by D. Kessel), Plenum Press, New York, pp. 111–114.CrossRefGoogle Scholar