Photobiology pp 743-748 | Cite as

Immunology of UV-Induced Human Skin Cancer

  • Gerda Frentz

Abstract

This paper focuses on photocarcinogenesis and non-melanoma skin cancer in man and discusses facts and theories on the role of the immune system for this process. Since photocarcinogenesis in man is closely connected with sun-exposure no details on the role of the specific wavelengths of UV radiation will be discussed.

Keywords

Dermatol Thymine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ananthaswamy, H.N., Price, J.E., Goldberg, L.H., Bales, E.S. (1988), Detection and identification of activated oncogenes in human skin cancers occurring on sun-exposed body sites, Cancer Res. 48:3341–3346.PubMedGoogle Scholar
  2. Bohr, V.A., Okumoto, D.S., Hanawalt, P.C.,(1986), Survival of UV-irradiated mammalian cells correlates with efficient DNA repair in an essential gene. Proc. Natl. Acad. Sci. USA 83:3830–3833.PubMedCrossRefGoogle Scholar
  3. Cleaver, J. (1968), Defective repair replication of DNA in Xeroderma pigmentosum, Nature 218:652–656.PubMedCrossRefGoogle Scholar
  4. Dubreuilh, W. (1896), Des hyperkeratoses circonscriptes, Ann. Dermatol. Syph (Series 3) 7:1158–1204.Google Scholar
  5. Epstein, J.H., Roth, H.L. (1968), Experimental ultraviolet carcinogenesis: a study of croton oil promoting effects. J. Invest. Dermatol. 50:387–389.PubMedGoogle Scholar
  6. Frentz, G, Munch-Petersen, B., Wulf, H.C., Niebuhr, E., da Cunha Bang, F. (1987), The nevoid basal cell carcinoma syndrome: sensitivity to ultraviolet radiation and X-rays, J. Am Acad. Dermatol. 17:637–643.PubMedCrossRefGoogle Scholar
  7. Frentz, G., dan Cunha Bang, F., Munch-Petersen, B., Lange, Wantzin, G. (1988), Increased number of circulating suppressor T-lymphocytes in sun-induced multiple skin cancers. Cancer 61: 294–297.PubMedCrossRefGoogle Scholar
  8. Guillen, F.J., Calvin, L. Day Jr, Murphy, G.F., (1985), Expression of human lymphocyte antigen (HLA)-DR on tumor cells in basal cell carcinoma, J. Am. Acad. Dermatol. 85:203–206.Google Scholar
  9. Gupta, A.K., Cardella, C.J., Habermann, H.F. (1986), Cutaneous malignant neoplasms in patients with renal transplants, Arch. Dermatol. 122:1288–1293.PubMedCrossRefGoogle Scholar
  10. Habets, J.M.W., Tank, B., Vuzevski, V.D., van Reede, E.C., Stolz, E., van Joost, T. (1988), Characterization of the mononuclear infiltrate in basal cell carcinoma: a predominantly Tcell-mediated immune response with minor participation of Leu-7+ (natural killer) cells and Leu-14+ (B) cells. J. Invest. Dermatol. 90:289–292.PubMedCrossRefGoogle Scholar
  11. Hersey, P., Haran, G., Hasic, E., Edwards, A. (1983), Alteration of T-cell subsets and induction of suppressor T-cell activity in normal subjects after exposure to sunlight, J. Immunol. 31:171–174.Google Scholar
  12. Hersey, P., Bradley, M., Hasic, E., Haran, G., Edwards, A., McCarthy, W.H. (1983), Immunological effects of solarium exposure in human subjects, Lancet 1:545–548.PubMedCrossRefGoogle Scholar
  13. Hersey, P., MacDonald, M., Burns, C., Schibeci, S., Matthews, H., Wilkinson, F.J. (1987), Analysis of the effect of a sunscreen agent on the suppression of natural killer cell activity induced in human subjects by radiation from solarium lamps, J. Invest. Dermatol. 88:271–276.PubMedCrossRefGoogle Scholar
  14. Hersey, P., MacDonald, M., Henderson, C., Schibeci, S., d’Allesandro, G., Pryor, M., Wilkinson, F.J. (1988), Suppression of natural killer cell activity in humans b y radiation from solarium lamps depleted of UVB, J. Invest. Dermatol. 90:305–310.PubMedCrossRefGoogle Scholar
  15. Kochiyama, A, Oka, D., Ueki, H. (1986), Immunohistologic studies of squamous cell carcinoma: possible participation of Leu-7+ (natural killer) cells as antitumor effector cells, J. Invest. Dermatol. 87:515–518.CrossRefGoogle Scholar
  16. Kochiyama, A., Oka, D., Ueki, H. (1987), Expression of human lymphocyte antigen (HLA)-DR on tumor cells in basal cell carcinoma, J. Am. Acad. Dermatol. 16:833–838.CrossRefGoogle Scholar
  17. Kripke, M.K. (1986), Immunology and photocarcinogenesis, New light on an old problem, J. Am. Acad. Dermatol. 14:149–155.PubMedCrossRefGoogle Scholar
  18. Munch-Petersen, B., Frentz, G. (1985), X-ray and UV-radiation sensitivity of circulating lymphocytes in multiple epidermal cancer in relation to previous radiation exposure, Rad. Res. 103:432–440.CrossRefGoogle Scholar
  19. Urbach, F. (1969), Geographic pathology of skin cancer, in Urbach F., ed: The biologic effects of ultraviolet radiation, Pergamon Press, Oxford, pp. 635–650.Google Scholar
  20. Unna, P.G. (1894), Die histopathologie der hautkrankheiten, Berlin, A. Hirschwald.Google Scholar
  21. Yagi, H., Danno, K., Maruguchi, Y., Yamamoto, M., Imamura, S. (1987), Significance of squamous cell carcinoma (SCC)-related antigens in cutaneous SCC. Arch. Dermatol. 123:902–906.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Gerda Frentz
    • 1
  1. 1.Dept of Reconstructive Surgery & Dept of DermatologyThe Finsen InstituteCopenhagenDenmark

Personalised recommendations