This paper focuses on photocarcinogenesis and non-melanoma skin cancer in man and discusses facts and theories on the role of the immune system for this process. Since photocarcinogenesis in man is closely connected with sun-exposure no details on the role of the specific wavelengths of UV radiation will be discussed.
KeywordsSkin Cancer Basal Cell Carcinoma Natural Killer Cell Activity Squamous Cell Cancer Xeroderma Pigmentosum
Unable to display preview. Download preview PDF.
- Dubreuilh, W. (1896), Des hyperkeratoses circonscriptes, Ann. Dermatol. Syph (Series 3) 7:1158–1204.Google Scholar
- Guillen, F.J., Calvin, L. Day Jr, Murphy, G.F., (1985), Expression of human lymphocyte antigen (HLA)-DR on tumor cells in basal cell carcinoma, J. Am. Acad. Dermatol. 85:203–206.Google Scholar
- Habets, J.M.W., Tank, B., Vuzevski, V.D., van Reede, E.C., Stolz, E., van Joost, T. (1988), Characterization of the mononuclear infiltrate in basal cell carcinoma: a predominantly Tcell-mediated immune response with minor participation of Leu-7+ (natural killer) cells and Leu-14+ (B) cells. J. Invest. Dermatol. 90:289–292.PubMedCrossRefGoogle Scholar
- Hersey, P., Haran, G., Hasic, E., Edwards, A. (1983), Alteration of T-cell subsets and induction of suppressor T-cell activity in normal subjects after exposure to sunlight, J. Immunol. 31:171–174.Google Scholar
- Hersey, P., MacDonald, M., Burns, C., Schibeci, S., Matthews, H., Wilkinson, F.J. (1987), Analysis of the effect of a sunscreen agent on the suppression of natural killer cell activity induced in human subjects by radiation from solarium lamps, J. Invest. Dermatol. 88:271–276.PubMedCrossRefGoogle Scholar
- Urbach, F. (1969), Geographic pathology of skin cancer, in Urbach F., ed: The biologic effects of ultraviolet radiation, Pergamon Press, Oxford, pp. 635–650.Google Scholar
- Unna, P.G. (1894), Die histopathologie der hautkrankheiten, Berlin, A. Hirschwald.Google Scholar