DNA Topology in Halobacteria
Inhibitors of eubacterial and eucaryotic DNA topoisomerases II induce topological changes and/or DNA cleavage in the plasmids of halobacteria. As in eubacteria, novobiocin halts DNA replication and induces positive supercoiling of plasmids in halobacteria. This positive supercoiling is prevented by actinomycin D, indicating that it may be generated by transcription as in eubacteria.
KeywordsReverse Gyrase Positive Supercoiling Thermophilic Archaebacterium Thermophilic Archae Reverse Gyrase Activity
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