Biochemical Characterization of Dihydrofolate Reductase of Halobacterium Volcanii

  • Tal Zusman
  • Moshe Mevarech
Part of the NATO ASI Series book series (NSSA, volume 201)

Abstract

The enzymatic activity of the enzyme dihydrofolate reductase of Halobacterium volcanii depends on salt concentration. the following communication describes the effect of salt concentration and pH on the catalytic parameters of this enzyme. In addition, the mode of inhibition of three different inhibitors of DHFR was studied.

Keywords

Catalysis Half Life Methotrexate Folic Acid NADPH 

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Tal Zusman
    • 1
  • Moshe Mevarech
    • 1
  1. 1.Department of Microbiology George S. Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael

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