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Cellular Signals Controlling Uterine Function pp 119–136Cite as

Uterine-conceptus Interactions During the Peri-implantation Period

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Summary

Interactions between the conceptus and endometrium of sheep and pigs are essential for establishment and maintenance of pregnancy. In pigs, estrogen-induced redirection of secretion of prostaglandin F 2 α (PGF) into the uterine lumen (exocrine secretion) is antiluteolytic, while sheep conceptuses secrete ovine trophoblast protein-1 which inhibits episodic secretion of PGF from the endometrium which is required for luteolysis. These antiluteolytic mechanisms insure maintenance of functional corpora lutea and secretion of progesterone which stimulates endometrial secretion of factors required to support the developing embryo/conceptus. These secretions include nutrients, as well as proteins that serve as enzymes, transport proteins, and regulatory proteins essential for establishment and maintenance of a successful pregnancy.

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  1. Departments of Animal Science and Pediatrics, University of Florida, Gainesville, 32611, Florida, USA

    F. W. Bazer

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  1. Wichita State University, Wichita, Kansas, USA

    Lynn A. Lavia

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Bazer, F.W. (1991). Uterine-conceptus Interactions During the Peri-implantation Period. In: Lavia, L.A. (eds) Cellular Signals Controlling Uterine Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3724-3_10

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  • DOI: https://doi.org/10.1007/978-1-4615-3724-3_10

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