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Differential Hybridization Analysis as a Tool to Study Prostatic Cancer Metastasis

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Molecular and Cellular Biology of Prostate Cancer

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Abstract

The progression of prostate cancer can be described in terms of growth rate, hormone responsiveness, histology and metastatic ability. Some of these parameters can be interdependent. Clearly, metastatic ability of tumor cells is clinically most significant. It is this process in which primary tumor cells spread through the body and grow out at secondary sites that leads to much of lethality due to cancer. For prostate cancer the clinical consequences of established metastatic disease are profound, since no curative therapy is available (1). Systemic palliative methods, based on androgen ablation, are usually succesful, but of limited duration. The outgrowth of androgen insensitive cells is inevitable, and will eventually result in the patients death (2).

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Author information

Authors and Affiliations

  1. Department of Urology, Urological Research Laboratory, University Hospital Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    Jack A. Schalken & Marion J. G. Bussemakers

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  1. Jack A. Schalken
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  2. Marion J. G. Bussemakers
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Editor information

Editors and Affiliations

  1. Office of Scientific Administration, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA

    James P. Karr Ph.D. (Chief) (Chief)

  2. The Johns Hopkins Hospital and University, Marburg Building, 600 North Wolfe Street, Baltimore, MD, 21205, USA

    Donald S. Coffey Ph.D. (Professor of Urology, Oncology and Pharmacology) (Professor of Urology, Oncology and Pharmacology)

  3. Department of Growth Biochemistry and Physiology, Merck, Sharpe and Dohme Research Lab, 126 East Lincoln Avenue, Rahway, NJ, 07065, USA

    Roy G. Smith Ph.D.

  4. Mayo Clinic, Guggenheim-4 200 First Street, SW, Rochester, MN, 55905, USA

    Donald J. Tindall Ph.D. (Professor of Urologic Research) (Professor of Urologic Research)

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© 1991 Springer Science+Business Media New York

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Schalken, J.A., Bussemakers, M.J.G. (1991). Differential Hybridization Analysis as a Tool to Study Prostatic Cancer Metastasis. In: Karr, J.P., Coffey, D.S., Smith, R.G., Tindall, D.J. (eds) Molecular and Cellular Biology of Prostate Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3704-5_38

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  • DOI: https://doi.org/10.1007/978-1-4615-3704-5_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6647-8

  • Online ISBN: 978-1-4615-3704-5

  • eBook Packages: Springer Book Archive

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