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Transforming Growth Factor α: A Potential Autocrine Growth Regulator in Prostatic Carcinoma

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Molecular and Cellular Biology of Prostate Cancer

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Abstract

Since the classical observation of Huggins and Hodges in 1941 [1], the efficacy of androgen-ablative therapy has been well established in the management of patients with advanced prostate cancer. However, this type of therapy remains palliative in nature. Although, initially patients with stage D disease are expected to experience beneficial responses to androgen ablation, the vast majority of them eventually will face progression of the disease despite the continuous androgen-depleted state [2]. This phenomenon is attributed to the presence in the primary and metastatic sites of an androgen-insensitive prostate cancer cell subset which is able to proliferate in the absence of any androgenic support [3]. Patients with androgenrefractory disease (stage D3) have a dismal prognosis with a mean survival period of less than one year [4], for existing therapeutic regimens are not effective for this group of patients [5]. Therefore, it is important to study the mechanisms through which these androgen-insensitive cells are able to escape androgendependency and become autonomous in cell proliferation.

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Author information

Authors and Affiliations

  1. Department of Urology, Urological Oncology Program, Northwestern University Medical School, Chicago, Illinois, 60611, USA

    Chung Lee, Darlys R. Hofer, Edward R. Sherwood & James M. Kozlowski

Authors
  1. Chung Lee
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  2. Darlys R. Hofer
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  3. Edward R. Sherwood
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  4. James M. Kozlowski
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Editor information

Editors and Affiliations

  1. Office of Scientific Administration, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA

    James P. Karr Ph.D. (Chief) (Chief)

  2. The Johns Hopkins Hospital and University, Marburg Building, 600 North Wolfe Street, Baltimore, MD, 21205, USA

    Donald S. Coffey Ph.D. (Professor of Urology, Oncology and Pharmacology) (Professor of Urology, Oncology and Pharmacology)

  3. Department of Growth Biochemistry and Physiology, Merck, Sharpe and Dohme Research Lab, 126 East Lincoln Avenue, Rahway, NJ, 07065, USA

    Roy G. Smith Ph.D.

  4. Mayo Clinic, Guggenheim-4 200 First Street, SW, Rochester, MN, 55905, USA

    Donald J. Tindall Ph.D. (Professor of Urologic Research) (Professor of Urologic Research)

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© 1991 Springer Science+Business Media New York

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Lee, C., Hofer, D.R., Sherwood, E.R., Kozlowski, J.M. (1991). Transforming Growth Factor α: A Potential Autocrine Growth Regulator in Prostatic Carcinoma. In: Karr, J.P., Coffey, D.S., Smith, R.G., Tindall, D.J. (eds) Molecular and Cellular Biology of Prostate Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3704-5_12

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  • DOI: https://doi.org/10.1007/978-1-4615-3704-5_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6647-8

  • Online ISBN: 978-1-4615-3704-5

  • eBook Packages: Springer Book Archive

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