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Protein C: Gene Structure and Protein Synthesis

  • George L. Long

Abstract

Protein C is a vitamin K-dependent plasma glycoprotein that, after activation by thrombin-thrombomodulin upon the endothelial cell surface, serves as a feedback down-regulator of the coagulation cascade by specifically degrading the protein cofactors VIIIa and Va (Figure 1). The biological role of protein C and the vascular endothelium has been recently reviewed in a succinct fashion1. Protein C in a less understood manner also enhances the process of fibrinolysis. Because of its antithrombotic as well as pro-fibrinolytic properties, protein C is considered to be a potential agent for antithrombotic therapy and a candidate for production by recombinant DNA technologies. The scope of this paper is to review: (i) the organization of the human protein C gene, particularly as it relates to the genes for homologous vitamin K-dependent proteins and to genetic protein C deficiency; and (ii) the biosynthesis of recombinant protein C in forms that are properly processed and biologically active.

Keywords

Human Protein Baby Hamster Kidney Amidolytic Activity Serine Protease Domain Genetic Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • George L. Long
    • 1
  1. 1.Department of BiochemistryUniversity of VermontBurlingtonCanada

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