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Alterations of Cell Surface Receptors and Expression of Cellular Oncogenes in the Liver of Rats Fed a Hypolipidemic Peroxisome Proliferator

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Chemical Carcinogenesis 2

Abstract

Hypolipidemic peroxisome proliferators (HPPs) consist of two classes of agent; one used in the treatment of hyperlipidemia and the other consisting of agents widely used in the industry as plasticizers such as phthalate esters1,2. When administered to experimental animals, HPPs induce marked hepatocellular hypertrophy and hyperplasia, hepatic peroxisome proliferation and an increase in the activity of several peroxisome associated enzymes2,3.

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Author information

Authors and Affiliations

  1. Cancer Center and Division of Environmental Science, Columbia University, College of Physicians and Surgeons, New York, NY, 10032, USA

    L. L. Hsieh & I. B. Weinstein

  2. Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15261, USA

    J. M. Betschart, M. A. Virji & H. Shinozuka

Authors
  1. L. L. Hsieh
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  2. I. B. Weinstein
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  3. J. M. Betschart
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  4. M. A. Virji
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  5. H. Shinozuka
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Editor information

Editors and Affiliations

  1. University of Cagliari, Cagliari, Italy

    Amedeo Columbano  & Paolo Pani  & 

  2. University of Sassari, Sassari, Italy

    Francesco Feo  & Rosa Pascale  & 

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Hsieh, L.L., Weinstein, I.B., Betschart, J.M., Virji, M.A., Shinozuka, H. (1991). Alterations of Cell Surface Receptors and Expression of Cellular Oncogenes in the Liver of Rats Fed a Hypolipidemic Peroxisome Proliferator. In: Columbano, A., Feo, F., Pascale, R., Pani, P. (eds) Chemical Carcinogenesis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3694-9_8

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  • DOI: https://doi.org/10.1007/978-1-4615-3694-9_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6642-3

  • Online ISBN: 978-1-4615-3694-9

  • eBook Packages: Springer Book Archive

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