Stimulus Dependent Phenotypic Diversity in the Resistant Hepatocyte Model
In the liver, hepatocytes recently initiated by chemical carcinogens show little outward sign of change (e.g. autonomy of growth). Almost all chemical carcinogens are cytotoxic in some way and one facet of this cytotoxicity can be an inhibition of cell proliferationl. Thus the acquisition of resistance to the cytotoxicity of a carcinogen by initiated cells offers an opportunity for such cells to gain a proliferative advantage over normal cells in an adverse environment. The basis for such resistance could be an alteration in the uptake, metabolism or excretion of the carcinogen2.
KeywordsHydrocarbon Adenosine Sarcoma Thymidine Tetrachloride
Unable to display preview. Download preview PDF.
- 5.M. R. Alison, C. J. Ryan, C. A. Lee, and K. McDermott, Compensatory hyperplasia in the rat liver as a result of cytoplasmic atrophy, Br. J. Exp. Path. 67:901 (1986).Google Scholar
- 9.M. R. Alison, M. J. E. Wilkins, S. M. Walker, and J. R. Hully, Cell population size control in the rat liver: the response of hepatocytes in various proliferative states to a mitogenic stimulus, Epithelia 1: 53 (1987).Google Scholar