Stimulus Dependent Phenotypic Diversity in the Resistant Hepatocyte Model

  • M. R. Alison
  • J. R. Hully


In the liver, hepatocytes recently initiated by chemical carcinogens show little outward sign of change (e.g. autonomy of growth). Almost all chemical carcinogens are cytotoxic in some way and one facet of this cytotoxicity can be an inhibition of cell proliferationl. Thus the acquisition of resistance to the cytotoxicity of a carcinogen by initiated cells offers an opportunity for such cells to gain a proliferative advantage over normal cells in an adverse environment. The basis for such resistance could be an alteration in the uptake, metabolism or excretion of the carcinogen2.


Partial Hepatectomy Cyproterone Acetate Portal Vein Ligation Basophilic Cell Mitogenic Stimulus 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • M. R. Alison
    • 1
  • J. R. Hully
    • 2
  1. 1.Department of HistopathologyRoyal Postgraduate Medical SchoolLondonUK
  2. 2.Laboratory for Cancer ResearchUniversity of WisconsinMadisonUSA

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