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Cancer Syndromes in Humans

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Chemical Carcinogenesis 2

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Abstract

An understanding of the genetic aspects of carcinogenesis in humans is important for the future of cancer prevention, detection and treatment. Evidence for the genetic basis of cancer includes inherited mutations and phenotypic malformations that are associated with specific tumors, hereditary neoplasms of childhood and adulthood, HLA-associated malignancies, and cancer family syndromes. Possible mechanisms to explain the evidence include: 1) abnormal development, 2) increased cell proliferation, 3) impaired immune response, 4) increased susceptibility to mutation, and 5) increased susceptibility to oncogenic viruses.

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Authors and Affiliations

  1. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA

    M. E. Kazanecki & T. J. Gill III

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  1. M. E. Kazanecki
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  1. University of Cagliari, Cagliari, Italy

    Amedeo Columbano  & Paolo Pani  & 

  2. University of Sassari, Sassari, Italy

    Francesco Feo  & Rosa Pascale  & 

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Kazanecki, M.E., Gill, T.J. (1991). Cancer Syndromes in Humans. In: Columbano, A., Feo, F., Pascale, R., Pani, P. (eds) Chemical Carcinogenesis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3694-9_14

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