Molecular Genetic Approach to Polygenic Disease: Non-Insulin Dependent Diabetes Mellitus (NIDDM)

  • M. Alan Permutt
  • Laszlo Koranyi
  • Akira Matsutani
Part of the NATO ASI Series book series (NSSA, volume 214)


Diabetes is a complex metabolic disorder of carbohydrate, lipid, and protein metabolism which is secondary to insulin deficiency. The insulin deficiency varies in degree, being complete in insulin dependent diabetes (IDDM), and relative in non-insulin dependent diabetes (NIDDM). The strong association of certain HLA immune-response genes on chromosome 6 with IDDM provides a prominent genetic marker to distinguish these two types of diabetes (Trucco and Dormon, 1989). This genetic marker serves to aid in genetic counseling and provides insight into the etiology of IDDM.


Restriction Fragment Length Polymorphism Insulin Receptor Human Insulin Insulin Gene Insulin Receptor Gene 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • M. Alan Permutt
    • 1
  • Laszlo Koranyi
    • 1
  • Akira Matsutani
    • 1
  1. 1.Metabolism DivisionWashington University School of MedicineSt. LouisUSA

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