Lactic Acid Bacteria in the Support of Immuno-compromised Hosts

  • Haruaki Tomioka
  • Hajime Saito

Abstract

Severe microbial infections are frequently present in immuno-compromised patients, such as due to malignant tumours, organ graft, thermal injury and in particular acquired immuno-deficiency syndrome (AIDS). In these cases, the opportunistic infections are generally caused by parasites with high drug resistance, such as aerobic or facultatively anaerobic Gram-negative rods (Pseudomonas, Xanthomonas, Achromobacter, Serratia, Klebsiella, Proteus, etc.), non-endospore-forming anaerobic rods (Bacteroides, Fusobacterium, etc.), Staphylococcus (especially methicillin-resistant S. aureus and cloxacillin-resistant S. epidermidis), non-tuberculous mycobacteria (Mycobacterium avium-intracellulare complex, M. scrofulaceum, M. kansasii, etc.), fungi (Candida, Aspergillus, Cryptococcus, etc.), viruses (Herpesvirus, Cytomegalovirus, etc.), and Protozoa (Pneumocystis carinii and Toxoplasma gondii). Thus, clinical control of the opportunistic infections using anti-microbials is very difficult, and a wide spectrum of disease manifestations, persistent infections, and disseminated diseases are frequently encountered. Therefore, it is important to provide a device to restore or enhance the lowered immune functions in compromised patients, using biological response modifiers (BRMs).

Keywords

Tuberculosis Polysaccharide Interferon Dexamethasone Pseudomonas 

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Copyright information

© Elsevier Science Publishers Ltd 1992

Authors and Affiliations

  • Haruaki Tomioka
    • 1
  • Hajime Saito
    • 1
  1. 1.Department of Microbiology and ImmunologyShimane Medical UniversityIzumo, ShimaneJapan

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