Lactic Acid Bacteria in the Support of Immuno-compromised Hosts

  • Haruaki Tomioka
  • Hajime Saito


Severe microbial infections are frequently present in immuno-compromised patients, such as due to malignant tumours, organ graft, thermal injury and in particular acquired immuno-deficiency syndrome (AIDS). In these cases, the opportunistic infections are generally caused by parasites with high drug resistance, such as aerobic or facultatively anaerobic Gram-negative rods (Pseudomonas, Xanthomonas, Achromobacter, Serratia, Klebsiella, Proteus, etc.), non-endospore-forming anaerobic rods (Bacteroides, Fusobacterium, etc.), Staphylococcus (especially methicillin-resistant S. aureus and cloxacillin-resistant S. epidermidis), non-tuberculous mycobacteria (Mycobacterium avium-intracellulare complex, M. scrofulaceum, M. kansasii, etc.), fungi (Candida, Aspergillus, Cryptococcus, etc.), viruses (Herpesvirus, Cytomegalovirus, etc.), and Protozoa (Pneumocystis carinii and Toxoplasma gondii). Thus, clinical control of the opportunistic infections using anti-microbials is very difficult, and a wide spectrum of disease manifestations, persistent infections, and disseminated diseases are frequently encountered. Therefore, it is important to provide a device to restore or enhance the lowered immune functions in compromised patients, using biological response modifiers (BRMs).


Lactic Acid Bacterium Peritoneal Macrophage Listeria Monocytogenes Host Resistance Thermal Injury 
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  1. Adams, D.O. (1982). Macrophage activation and secretion. Summary. Federation Proceedings, 41, 2193–7.Google Scholar
  2. Allison, A.C. (1979). Mode of action of immunological adjuvants. Journal of Reticuloendothelial Society, 26, 619–30.Google Scholar
  3. Bermudez, L.E.M. & Young, L.S. (1988). Tumour necrosis factor, alone or in combination with IL-2, but not IFN-γ, is associated with macrophage killing of Mycobacterium avium complex. Journal of Immunology, 140, 3006–13.Google Scholar
  4. Bjornson, A.B., Bjornson, H.S. & Altemeier, W.A. (1981). Serum-mediated inhibition of polymorphonuclear leukocyte function following burn injury. Annals of Surgery, 194, 568–75.CrossRefGoogle Scholar
  5. Bloksma, N., Heer, E., de, Dijk, H., van & Willers, J.M. (1979). Adjuvanticity of lactobacilli. I. Differential effects of viable and killed bacteria. Clinical and Experimental Inmmunology,37, 367–75.Google Scholar
  6. Bogdanov, I.G. & Daley, P.G. (1975). Antitumour glycopeptide from Lactobacillus bulgaricus cell wall. FEBS Letters, 57, 259–61.CrossRefGoogle Scholar
  7. Boros, T. & Rapp, H. J. (1973). Conference on the use of BCG in therapy of cancer. National Cancer Institute Monograph, 39.Google Scholar
  8. Campbell, P.A. (1976). Immunocompetent cells in resistance to bacterial infections. Bacteriological Reviews, 40, 284–313.Google Scholar
  9. Chedid, L. & Audibert, F. (1977). Chemically defined bacterial products with immunopotentiating activity. Journal of Infectious Diseases, 136, S246–51.CrossRefGoogle Scholar
  10. Chedid, L., Audibert, F. & Johnson, A.G. (1978). Biological activities of muramyl dipeptide, a synthetic glycopeptide analogue to bacterial immunoregulating agents. Progress in Allergy, 25, 63–105.Google Scholar
  11. Cheers, C. & McKenzie, I.F.C. (1978). Resistance and susceptibility of mice to bacterial infection: Genetics of listeriosis. Infection and Immunity, 19, 755–62.Google Scholar
  12. Cheers, C. & Stanley, E.R. (1988). Macrophage production during murine listeriosis: Colony-stimulating factor (CSF-1) and CSF-1-binding cells in genetically resistant and susceptible mice. Infection and Immunity,56, 2972–8.Google Scholar
  13. Cheers, C., McKenzie, I.F.C., Pavlov H., Waid, C. & York, J. (1978) Resistance and susceptibility of mice to bacterial infection: Course of listeriosis in resistant or susceptible mice. Infection and Immunity, 19,763–70.Google Scholar
  14. Chirigos, M.A., Saito, T., Talmadge, J.E., Budzynski, W., Sinibaldi, P. & Gruys, E. (1986). The immunomodulatory and therapeutic activity of Picibanil (OK-432). In Mechanisms of Antitumor Effects of OK-432, ed. N. Ishida. Excerpta Medica, Tokyo, Japan, pp. 1–9.Google Scholar
  15. Czuprynsky, C.J., Campbell, P.A. & Henson, P.M. (1983). Killing of Listeria monocytogenes by human neutrophils and monocytes, but not by monocyte-derived macrophages. Journal of Reticuloendothelial Society, 34, 29–44.Google Scholar
  16. Dye, E.S., North, R.J. & Mills, C.D. (1981). Mechanisms of antitumour action of Corynebacterium parvum. Journal of Experimental Medicine,154, 609–20.CrossRefGoogle Scholar
  17. Edwards, D. & Kirkpatrick, C.H. (1986). The immunology of mycobacterial diseases. American Review of Respiratory Disease, 134, 1062–71.Google Scholar
  18. Emmerling, P., Finger, H. & Hof, H. (1977). Cell-mediated resistance to infection with Listeria monocytogenes in nude mice. Infection and Immunity, 15, 382–5.Google Scholar
  19. Esparza, I., Männel, D., Ruppel, A., Falk, W. & Krammer, P.H. (1987). Interferon γ and lyphotoxin or tumor necrosis factor act synergistically to induce macrophage killing of tumor cells and schistosomula of Schistosoma mansoni. Journal of Experimental Medicine, 166, 589–94.CrossRefGoogle Scholar
  20. Ferrante, A. (1989). Tumor necrosis factor alpha potentiates neutrophil antimicrobial activity: Increased fungicidal activity against Torulopsis glabrata and Candida albicans and associated increases in oxygen radical production and lysosomal enzyme release. Infection and Immunity, 57, 2115–22.Google Scholar
  21. Gangadharam, P.R.J., Edwards III, C.K., Murthy, P.S. & Pratt, P.F. (1983). An acute infection model for Mycobacterium intracllulare disease using beige mice: Preliminary results. American Review of Respiratory Disease,127, 648–9.Google Scholar
  22. Garcia-Penarrubia, P., Bankhurst, A.D. & Koster, F.T. (1989a). Experimental and theoretical kinetics study of antibacterial killing mediated by human natural killer cells. Journal of Immunology, 142, 1310–17.Google Scholar
  23. Garcia-Peñarrubia, P., Lennon, M.P., Koster, F.T., Kelley R.O. & Bankhurst, A.D. (1989b). Selective proliferation of natural killer cells among monocyte-depleted peripheral blood mononuclear cells as a result of stimulation with staphylococcal enterotoxin B. Infection and Immunity, 57, 2057–65.Google Scholar
  24. Garcia-Peñarrubia, P., Koster, F.T., Kelley, R.O., McDowell, T.D. & Bankhurst, A.D. (1989c). Antibacterial activity of human natural killer cells. Journal of Experimental Medicine, 169, 99–113.CrossRefGoogle Scholar
  25. Glasgow, L.A., Fischbach, J., Bryant, S.M. & Kern, E.R. (1977). Immunomodulation of host resistance to experimental viral infections in mice: effects of Corynebacterium acnes, Corynebacterium parvum, and Bacille Calmette-Guérin. Journal of Infectious Diseases, 135, 763–70.CrossRefGoogle Scholar
  26. Gorelik, E., Wiltrout, R.H., Okumura, K., Habu, S. & Herberman, R.B. (1982). Role of NK cells in the control of metastatic spread and growth of tumor cells in mice. International Journal of Cancer, 30, 107–12.CrossRefGoogle Scholar
  27. Grabstein, K.H., Urdal, D.L., Tushinski, R.J., Mochizuki, D.Y., Price, V.L., Cantrell, M.A., Gillis, S. & Conlon, P.J. (1986). Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor. Science,232,506–8.CrossRefGoogle Scholar
  28. Grogan, J.B. (1976a) Altered neutrophil phagocytic function in burn patients. Journal of Trauma, 16, 734–8.CrossRefGoogle Scholar
  29. Grogan, J.B, (1976b). Suppressed in vitro chemotaxis of burn neutrophils. Journal of Trauma, 16, 985–8.CrossRefGoogle Scholar
  30. Halpern, B., Fray, A., Grepin, Y., Platica, O., Lornet, A.M., Rabourdin, A., Sparros, L. & Isac, R. (1973). Corynebacterium parvum, a potent immunostimulant in experimental infections and malignancies. In Immunopotentiation (A Ciba Foundation Symposium 18 (new series)), ed. P. Medawar. Elsevier Excerpta Medica, Amsterdam, The Netherlands, pp. 217–36.CrossRefGoogle Scholar
  31. Harrington-Fowler, L., Henson, P.M. & Wilder, M.S. (1981). Fate of Listeria monocytogenes in resident and activated macrophages. Infection and Immunity, 33, 11–16.Google Scholar
  32. Hashimoto, S., Nomoto, K., Matsuzaki, T., Yokokura, T. & Mutai, M. (1984). Oxygen radical production by peritoneal macrophages and Kupffer cells elicited with Lactobacillus casei. Infection and Immunity,44, 61–7.Google Scholar
  33. Hashimoto, S, Nomoto, K., Nagaoka, M. & Yokokura, T. (1987). In vitro and in vivo release of cytostatic factors from Lactobacillus casei-elicited peritoneal macrophages after stimulation with tumor cells and immunostimulants. Cancer Immunology Immunotherapy, 24, 1–7.CrossRefGoogle Scholar
  34. Horikawa, Y. (1986). Effects of Lactobacillus casei-containing ointment on the healing and protection against opportunistic infection of thermal injury wounds in mice. Hiroshima Journal of Medical Sciences, 35, 1–14.Google Scholar
  35. Johnston Jr., R.B. (1978). Oxygen metabolism and the microbicidal activity of macrophages. Federation Proceedings,37,2759–64.Google Scholar
  36. Kato, I., Kobayashi, S., Yokokura, T. & Mutai, M. (1981). Antitumor activity of Lactobacillus casei in mice. Gann, 72, 517–23.Google Scholar
  37. Kato, I., Yokokura, T. & Mutai, M. (1983). Macrophage activation by Lactobacillus casei in mice. Microbiology and Immunology, 27, 611–18.Google Scholar
  38. Kato, I., Yokokura, T. & Mutai, M. (1984). Augmentation of mouse natural killer cell activity by Lactobacillus casei and its surface antigens. Microbiology and Immunology, 28, 209–17.Google Scholar
  39. Kato, I., Yokokura, T. & Mutai, M. (1988). Correlation between increase in Ia-bearing macrophages and induction of T cell-dependent antitumor activity by Lactobacillus casei in mice. Cancer Immunology Immunotherapy,26,215–21.CrossRefGoogle Scholar
  40. Kratz, S.S. & Kurlander, R.J. (1988). Characterization of the pattern of inflammatory cell influx and cytokine production during the murine host response to Listeria monocytogenes. Journal of Immunology, 141, 598–606.Google Scholar
  41. Kurtz, R.S., Young, K.M. & Czuprynski, C.J. (1989). Separate and combined effects of recombinant interleukin-lα and gamma interferon on antibacterial resistance. Infection and Immunity, 57,553–8.Google Scholar
  42. Loose, L.D. & Turinsky, J. (1980). Depression of the respiratory burst in alveolar and peritoneal macrophages after thermal injury. Infection and Immunity, 30, 718–22.Google Scholar
  43. Mackaness, G.B. (1969). The influence of immunologically committed lymphoid cells on macrophage activity. Journal of Experimental Medicine, 129, 973–92.CrossRefGoogle Scholar
  44. Mandel, T.E. & Cheers, C. (1980). Resistance and susceptibility of mice to bacterial infection: Histology of Isteriosis in resistant and susceptible strains. Infection and Immunity, 30, 851–61.Google Scholar
  45. Matsumoto, K., Ogawa, H., Nagase, O., Kusama, T. & Azuma, I. (1981). Stimulation of nonspecific host resistance to infection induced by muramyl dipeptides. Microbiology and Immunology,25, 1047–58.Google Scholar
  46. Metcalf, D. (1984). The colony stimulating factors. In The Hemopoietic Colony Stimulating Factors, ed. D. Metcalf. Elsevier/North-Holland Publishing Co., Amsterdam, The Netherlands, pp. 55--96.Google Scholar
  47. Miake, S., Nomoto, K., Yokokura, T., Yoshikai, Y., Mutai, M. & Nomoto, K. (1985). Protective effect of Lactobacillus casei on Pseudomonas aeruginosa infection in mice. Infection and Immunity, 48, 480–5.Google Scholar
  48. Miller, C.L. & Baker, C.C. (1979). Changes in lymphocyte activity after thermal injury. The role of suppressor cells. Journal of Clinical Investigation,63, 202–10.CrossRefGoogle Scholar
  49. Mitsuyama, M., Takeya, K., Nomoto, K. & Shimotori, S. (1978). Three phases of phagocyte contribution to resistance against Listeria monocytogenes. Journal of General Microbiology, 106, 165–71.Google Scholar
  50. Miyajima, A., Miyatake, S., Schreurs, J., Vries, J., de Arai, N., Yokota, T. & Arai, K. (1988). Coordinate regulation of immune and inflammatory responses by T cell-derived lymphokines. FASEB Journal, 2, 2462–73.Google Scholar
  51. Moore, R.N., Oppenheim, J.J., Farrar, J.J., Carter Jr. C.S., Waheed, A. & Shadduck, R.K. (1980). Production of lymphocyte-activating factor (interleukin 1) by macrophages activated with colony-stimulating factors. Journal of Immunology,125, 1302–5.Google Scholar
  52. Morahan, P.S., Edelson, P.J. & Gass, K. (1980). Changes in macrophage ectoenzymes associated with antitumor activity. Journal of Immunology, 125, 1312–17.Google Scholar
  53. Morton, D.L., Eilber, F.R., Malmgren, R.A. & Wood, W.C. (1970). Immunological factors which influence response to immunotherapy in malignant melanoma. Surgery,68, 158–64.Google Scholar
  54. Murray, H.W. (1988). Interferon-gamma. The activated macrophage and host defense against microbial challenge. Annals of Internal Medicine,108, 595–608.Google Scholar
  55. Murray, H.W., Rubin, B.F. & Rothermel, C.D. (1983). Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-γ is the activating lymphokine. Journal of Clinical Investigation, 72, 1506–10.CrossRefGoogle Scholar
  56. Nakane, A., Minagawa, T. & Kato, K. (1988). Endogenous tumor necrosis factor (cachectin) is essential to host resistance against (Listeria monocytogenes infection. Infection and Immunity, 56, 2563–9.Google Scholar
  57. Nanno, M., Ohwaki, M. & Mutai, M. (1986). Induction by Lactobacillus casei of increase in macrophage colony-forming cells and serum colony-stimulating activity in mice. Japanese Journal of Cancer Reseach, 77, 703–10.Google Scholar
  58. Nanno, M., Shimizu, T., Mike, A., Ohwaki, M. & Mutai, M. (1988). Role of macrophages in serum colony-stimulating factor induction by Lactobacillus casei in mice. Infection and Immunity, 56, 357–62.Google Scholar
  59. Nathan, C.F. (1983). Mechanisms of macrophage antimicrobial activity. Transac-tions of the Royal Society of Tropical Medicine and Hygiene, 77, 620–30.CrossRefGoogle Scholar
  60. Nencioni, L., Villa, L., Boraschi, D., Berti, B. & Tagliabue, A. (1983). Natural and antibody-dependent cell-mediated activity against Salmonella typhimurium by peripheral and intestinal lymphoid cells in mice. Journal of Immunology,130, 903–7.Google Scholar
  61. Newborg, M.F. & North, R.J. (1980). On the mechanism of T cell-independent anti-Listeria resistance in nude mice. Journal of Immunology, 124, 571–6.Google Scholar
  62. Ninnemann, J.L. & Stockland, A.E. (1984). Participation of prostaglandin E in immunosuppression following thermal injury. Journal of Trauma,24, 201–7.CrossRefGoogle Scholar
  63. North, R. J. (1970). The relative importance of blood monocytes and fixed macrophages to the expression of cell-mediated immunity to infection. Journal of Experimental Medicine,132, 521–34.CrossRefGoogle Scholar
  64. North, R.J. (1974). T cell dependence of macrophage activation and mobilization during infection with Mycobacterium tuberculosis. Infection and Immunity, 10, 66–71.Google Scholar
  65. Old, L.J. (1985). Tumor Necrosis Factor (TNF). Science, 230, 630–2.CrossRefGoogle Scholar
  66. Perdigon, G., Macias, M.E.N., Alvarez, S., Oliver, G. & Ruiz Holgardo, A.A.P. (1986). Effect of perorally administered lactobacilli on macrophage activation in mice. Infection and Immunity, 53, 404–10.Google Scholar
  67. Perdigon, G., Macias, M.E.N., Alvarez, S., Oliver, G. & Ruiz Holgardo, A.A.P. (1988). Systemic augmentation of the immune response in mice by feeding fermented milks with Lactobacillus casei andLactobacillus acidophilus. Immunology, 63, 17–23.Google Scholar
  68. Petkus, A.F. & Baum, L.L. (1987). Natural killer cell inhibition of young spherules and endospores of Coccidioides immitis. Journal of Immunology, 139, 3107–11.Google Scholar
  69. Rahman, M. (1982). Chest infection caused by Lactobacillus casei ss rhamnosus.British Medical Journal [Clinical Research], 284, 471–2. CrossRefGoogle Scholar
  70. Roder, J.C., Kiessling, R., Biberfeld, P. & Andersson, B. (1978). Target-effector interaction in the natural killer (NK) cell system. II The isolation of NK cells and studies on the mechanism of killing. Journal of Immunology,121, 2509–17.Google Scholar
  71. Ruco, L.P. & Meltzer, M.S. (1978). Macrophage activation for tumor cytotoxicity: Development of macrophage cytotoxic activity required completion of a sequence of short-lived intermediary reactions. Journal of Immunology, 121, 2035–42.Google Scholar
  72. Saito, H. (1988). Enhancement of host resistance to bacterial and viral infections by Lactobacillus casei. Bifidobacteria Microflora,7, 1–18.Google Scholar
  73. Saito, H., Watanabe, T., Horikawa, Y. & Tado, O. (1980a). Resistance of mice treated with Lactobacillus casei against infections with Serratia marcescens, Klebsiella pneumoniae and Candida albicans. Medicine and Biology (Tokyo), 101, 29–32.Google Scholar
  74. Saito, H., Watanabe, T., Horikawa, Y. & Tado, O. (1980b). Protective effects of lactobacilli on experimental Escherichia coli infection. Medicine and Biology (Tokyo), 101, 61–4.Google Scholar
  75. Saito, H., Watanabe, T. & Horikawa, Y. (1981a). Enhanced resistance of Lactobacillus against the opportunistic infection in mice. Medicine and Biology (Tokyo), 102, 309–14.Google Scholar
  76. Saito, H., Tomioka, H. & Sato, K. (1981b). Enhanced resistance of Lactobacillus casei against Listeria infection in mice. Medicine and Biology (Tokyo), 102, 273–7.Google Scholar
  77. Saito, H., Watanabe, T. & Horikawa, Y. (1982a). Protective effects of a Lactobacillus preparation, LC-9018, on the experimental Pseudomonas aeruginosa infection in mice. Medicine and Biology (Tokyo), 104, 283–7.Google Scholar
  78. Saito, H., Sato, K. & Tomioka, H. (1982b). Enhanced resistance of LC-9018 against Listeria infection in mice. Medicine and Biology (Tokyo), 104, 171–5.Google Scholar
  79. Saito, H., Nagashiman, K. & Tomioka, H. (1983). Effects of bacterial immunopotentiators, LC 9018 and OK-432, on the resistance against Mycobacterium intracellulare infection in mice. Hiroshima Journal of Medical Sciences, 32, 145–8.Google Scholar
  80. Saito, H., Watanabe, T., Kitagawa, T. & Asano, K. (1985). Protective effects of bacterial immunostimulants, OK-432 and LC 9018, on Pseudomonas aeruginosa infection in tumor-bearing mice. Hiroshima Journal of Medical Sciences, 34, 459–62.Google Scholar
  81. Saito, H., Watanabe, T. & Horikawa, Y. (1986). Effects of Lactobacillus casei on Pseudomonas aeruginosa infection in normal and dexamethasone-treated mice. Microbiology and Immunology, 30, 249–59.Google Scholar
  82. Saito, H., Tomioka, H. & Nagashima, K. (1987). Protective and therapeutic efficacy of Lactobacillus casei against experimental murine infections due to Mycobacterium fortuitum complex. Journal of General Microbiology, 133, 2843–51.Google Scholar
  83. Sato, K. (1984). Enhancement of most resistance against Listeria infection by Lactobacillus casei: Role of macrophages. Infection and Immunity, 44, 445–51.Google Scholar
  84. Sato, K. Saito, H. & Tomioka, H. (1988a). Enhancement of most resistance against Listeria infection by Lactobacillus casei: Activation of liver macrophages and peritoneal macrophages by Lactobacillus casei. Microbiology and Immunology,32, 689–98.Google Scholar
  85. Sato, K. Saito, H., Tomioka, H. & Yokokura, T. (1988b). Enhancement of most resistance against Listeria infection by Lactobacillus casei: Efficacy of cell wall preparation of Lactobacillus casei. Microbiology and Immunology 32, 1189–1200.Google Scholar
  86. Shellam, G.R., Allan, J.E., Papadimitriou, J.M. & Bancroft, G.J. (1981). Increased susceptibility to cytomegalovirus infection in beige mutant mice. Proceedings of the National Academy of Science USA, 78, 5104–8.CrossRefGoogle Scholar
  87. Smith, K.A. (1988). Interleukin-2: Inception, impact, and implications. Science, 240, 1169–76.CrossRefGoogle Scholar
  88. Sorrell, T.C., Lehrer, R.I. & Cline, M.J. (1978). Mechanism of nonspecific macrophage-mediated cytotoxicity: Evidence for lack of dependence upon oxygen. Journal of Immunology, 120, 347–52.Google Scholar
  89. Sussman, J.I., Baron, E.J., Goldberg, S.M., Kaplan, M.H. & Pizzarello, R.A. (1986). Clinical manifestations and therapy of Lactobacillus endocarditis: Report of a case and review of the literature. Reviews of Infectious Diseases, 8, 771–6.CrossRefGoogle Scholar
  90. Swartzberg, J.E., Krahenbuhl, J.L. & Remington, J.S. (1975). Dichotomy between macrophage activation and degree of protection against Listeria onocytogenes and Toxoplasma gondii in mice stimulated with Corynebacterium parvum. Infection and Immunity, 12, 1037–43.Google Scholar
  91. Tatsukawa, K., Mitsuyama, M., Takeya, K. & Nomoto, K. (1979). Differing contribution of polymorphonuclear cells and macrophages to protection of mice against Listeria monocytogenes and Pseudomonas aeruginosa. Journal of General Microbiology, 115, 161–6.Google Scholar
  92. Tomioka, H., Sato, K. & Saito, H. (1990). Combined effect of ofloxacin with Lactobacillus casei against Mycobacterium fortuitum infection induced in mice. Antimicrobial Agents and Chemotherapy, 34, 632–6.Google Scholar
  93. Valone, S.E., Rich, E.A., Wallis, R.S. & Ellner, J.J. (1988). Expression of tumor necrosis factor in vitro by human mononuclear phagocytes stimulated with whole Mycobacterium bovis BCG and mycobacterial antigens. Infection and Immunity, 56, 3313–15.Google Scholar
  94. Winchurch, R.A. & Munster, A.M. (1980). Post-tramatic activation of suppressor cells. Journal of Reticuloendothelial Society, 27,83–8.Google Scholar
  95. Wing, E.J., Ampel, E.M., Waheed, A. & Shadduck, R.K. (1985). Macrophage colony-stimulating factor (M-CFS) enhances the capacity of murine macrophages to secrete oxygen reduction products. Journal of Immunology, 135,2052–6.Google Scholar
  96. Wolfe, J.H.N., Saporoschetz, I., Young, A.E., O’Connor, N.E. & Mannick, J.A. (1981). Suppressive serum, suppressive lymphocytes, and death from burns. Annals of Surgery, 193, 513–20.Google Scholar
  97. Woodruff, M.F.A. & Dunbar, N. (1973). The effect of Corynebacterium parvum and other reticuloendothelial stimulants on transplanted tumours in mice. In Immunopotentiation (A Ciba Foundation Symposium 18 (new series)),ed. P. Medawar, Elsevier Excerpta Medica, Amsterdam, The Netherlands, pp. 287–303.CrossRefGoogle Scholar
  98. Woods, G.L. & Washington, J.A. II. (1987). Mycobacteria other than Mycobacterium tuberculosis: Review of microbiological and clinical aspects. Reviews of Infectious Diseases, 9, 275–94.CrossRefGoogle Scholar
  99. Yamada, Y., Jidoi, J., Saito, H. & Tomioka, H. (1988). Changes in the function of macrophages after thermal injury and effect of Lactobacillus casei on function of macrophages. Journal of the Japanese Association for Infectious Diseases, 62, 557–63.Google Scholar

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© Elsevier Science Publishers Ltd 1992

Authors and Affiliations

  • Haruaki Tomioka
    • 1
  • Hajime Saito
    • 1
  1. 1.Department of Microbiology and ImmunologyShimane Medical UniversityIzumo, ShimaneJapan

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