Inhibitors of Prostaglandin Synthesis in Cancer Chemoprevention
Chemoprevention which focuses on the inhibition of carcinogenesis by chemical agents, both synthetic and naturally occurring, is a concept that these substances could inhibit partially or totally the development of neoplasms. Several naturally-occurring substances and synthetic chemicals have been intensely investigated for their chemopreventive action on chemically-induced neoplasms of various organ sites (1) Arachidonic acid, a precursor of several biologically active prostaglandins (PGs), is the most abundant polyenoic fatty acid found in the phospholipids of mammalian tissues. A number of experimental animal tumors and human cancers have been shown to contain and/or produce large quantities of PGs, particularly those of E series (2). PGs have been shown to significantly affect cell proliferation and tumor growth in a variety of experimental situations. Therefore, the possibility exists that the modulation of production of PGs may influence the tumorigenesis. This paper reviews the relationship between the inhibitors of PG synthesis and cancer prevention with special reference to cancer of the colon.
KeywordsAdenocarcinoma Adenoma Prostaglandin Indomethacin PGE2
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- 1.Boon, C.W., Kelloff, G. and Malone, W.E. Cancer Res. 50:29, 1990.Google Scholar