Abstract
Chronic inflammation from chronic infections or smoking is a major risk factor for cancer. The toxic oxidants released by phagocytes damage DNA directly and, in order to promote wound healing, are also signals for mitogenesis. The inflammation-induced mutagenesis and mitogenesis produce a synergistic response that contributes to cancer. The inflammatory response can be mitigated by antioxidants and other dietary factors.
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References
Ames, B.N. and Gold, L.S. Proc. Natl. Acad. Sci. USA. 87:7772–7776, 1990.
Ames, B.N. and Gold, L.S. Mut. Res., in press.
Weitzman, S.A. and Gordon, L., I. Blood. 76:655–663, 1990.
Fraga, C.G., Shigenaga, M.K., Park, J.-W., Degan, P. and Ames, B.N. Proc. Natl. Acad. Sci. 87:4533–4537, 1990.
Carney, J.M., Starke-Reed, P.E., Oliver, C.N., Landum, R.W., Cheng, M.S., Wu, J.F. and Floyd, R.A. Proc. Natl. Acad. Sci. USA. 88:3633–3636, 1991.
Burdon, R.H., Gill, V. and Rice-Evans, C. Free Rad. Res. Comms. 11:65–76, 1990.
Chan, T.M., Chen, E., Tatoyan, A., Shargill, N.S., Pleta, M. and Hochstein, P. Biochem. Biophys. Res. Commun. 139:439–445, 1986.
Craven, P.A., Pfanstiel, J. and DeRubertis, F.R. J. Clin. Invest. 79:532–541, 1987.
Abate, C., Patel, L., Rauscher, F.J., III and Curran, T. Science 249:1157–1161, 1990.
Shacter, E., Beecham, E.J., Covey, J.M., Kohn, K.W. and Potter, M. Carcinogenesis 9:2297–2304, 1988.
Yamashina, K., Miller, B.E. and Heppner, G.H. Cancer Res. 46:2396–2401, 1986.
Lewis, J.G. and Adams, D.O. Environ. Health Perspect. 76:19–27, 1987.
Madsen, C. Lab. Anim. 23:241–247, 1989.
Templeton, A. J. Environ. Pathol. Toxicol. 3:387–397, 1980.
Shopland, D.R., Eyre, H.J. and Pechacek, T.F. J. Natl. Cancer Inst. 83:1142–1148, 1991.
Parsonnet, J., Vandersteen, D., Goates, J., Sibley, R.K., Pritikin, J. and Chang, Y. J. Natl. Cancer Inst. 83:640–643, 1990.
Block, G. Am. J. Clin. Nutr. 53:270S–282S, 1991.
Knekt, P., Aromaa, A., Maatela, J., Aaran, R.-K., Nikkari, T., Hakama, M., Hakulinen, T., Peto, R. and Teppo, L. Am. J. Clin. Nutr. 53:283S–286S, 1991.
Gey, K.F., Puska, P. and Jordan, P. (1991) Am. J. Clin. Nutr. 53:326S–334S, 1991.
Robertson, J.McD., Donner, A.P. and Trevithick, J.R. Am. J. Clin. Nutr. 53:346S–351S, 1991.
Comstock, G.W., Helzlsouer, K.J. and Bush, T.L. Am. J. Clin. Nutr. 53:260S–264S, 1991.
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Ames, B.N., Hagen, T.M., Shigenaga, M.K. (1993). Chronic Inflammation is a Major Cause of Preventable Cancer. In: Nigam, S., Honn, K.V., Marnett, L.J., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury. Developments in Oncology, vol 71. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3520-1_74
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