Chronic Inflammation is a Major Cause of Preventable Cancer

  • B. N. Ames
  • T. M. Hagen
  • M. K. Shigenaga
Part of the Developments in Oncology book series (DION, volume 71)

Abstract

Chronic inflammation from chronic infections or smoking is a major risk factor for cancer. The toxic oxidants released by phagocytes damage DNA directly and, in order to promote wound healing, are also signals for mitogenesis. The inflammation-induced mutagenesis and mitogenesis produce a synergistic response that contributes to cancer. The inflammatory response can be mitigated by antioxidants and other dietary factors.

Keywords

Hepatitis Lymphoma Adduct Folic Acid Cataract 

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • B. N. Ames
    • 1
  • T. M. Hagen
    • 1
  • M. K. Shigenaga
    • 1
  1. 1.Division of Biochemistry and Molecular Biology, Barker HallUniversity of CaliforniaBerkeleyUSA

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