Chronic Inflammation is a Major Cause of Preventable Cancer

  • B. N. Ames
  • T. M. Hagen
  • M. K. Shigenaga
Part of the Developments in Oncology book series (DION, volume 71)


Chronic inflammation from chronic infections or smoking is a major risk factor for cancer. The toxic oxidants released by phagocytes damage DNA directly and, in order to promote wound healing, are also signals for mitogenesis. The inflammation-induced mutagenesis and mitogenesis produce a synergistic response that contributes to cancer. The inflammatory response can be mitigated by antioxidants and other dietary factors.


Chronic Inflammation Chronic Infection Major Risk Factor Promote Wound Healing Toxic Oxidant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • B. N. Ames
    • 1
  • T. M. Hagen
    • 1
  • M. K. Shigenaga
    • 1
  1. 1.Division of Biochemistry and Molecular Biology, Barker HallUniversity of CaliforniaBerkeleyUSA

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