Abstract
Platelet-activating factor (PAF) is a phospholipid mediator of inflammation and anaphylaxis released by a variety of cell types. This study demonstrates that PAF is among the most potent biological radioprotectors known. PAF (300 μg/kg) given subcutaneously (s.c.) to CD2F1 male mice 5–10 minutes before irradiation increased survival by a factor of 1.7. This radioprotective efficacy was eliminated or reduced when dexamethasone was administered within 24 h before irradiation, 2 h after irradiation, or by an earlier PAF treatment 1 h before an otherwise radioprotective PAF dose. Protection was also attenuated by pretreatment with the PAF-specific antagonist, U-66985. Therefore, protection may be mediated by direct action on PAF-specific receptors in combination with indirect systemic events initiated by receptor activation.
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Walden, T.L., Steel, L.K., Hughes, H.N. (1993). Radioprotective Efficacy of Platelet Activating Factor in Mice. In: Nigam, S., Honn, K.V., Marnett, L.J., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury. Developments in Oncology, vol 71. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3520-1_71
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DOI: https://doi.org/10.1007/978-1-4615-3520-1_71
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