Abstract
A variety of eicosanoids and their analogs protect tissues, in vivo, from ionizing radiation. Although the specific mechanism(s) remain elusive, comparative studies of clasśes of eicosanoids suggest that there are differences in protective characteristics. Protective PGs of the E-series were dependent upon glucocorticoids (GCs). In contrast, protection by the PGI2 analog iloprost (Schering AG, Berlin) or LTC4 was independent of GCs. When radiosensitivity was measured after multiple injections of E-series eicosanoids, there was a decrease or a plateau of protection similar to a single dose. Protection in animals given iloprost continued to increase with each dose. These data suggests that at least two separate pathways lead to eicosanoid-induced radioprotection.
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Hanson, W.R., Duffner, L.A. (1993). Variations in the Profiles of Radioprotective Eicosanoids. In: Nigam, S., Honn, K.V., Marnett, L.J., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury. Developments in Oncology, vol 71. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3520-1_65
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