Properties and Functions of an Epidermal 8-Lipoxygenase

  • G. FüRstenberger
  • T. Jacobi
  • B. Schurich
  • M. LöSchke
  • W. D. Lehmann
  • M. Stephan
  • F. Marks
Part of the Developments in Oncology book series (DION, volume 71)

Abstract

Skin epidermis in vivo or keratinocytes in culture express a broad spectrum of polyunsaturated fatty acid-metabolizing activities especially when challenged by toxic agents, irritants or certain endogenous factors (for review see ref. 1). Among the multiple changes in epidermal arachidonic acid metabolism induced by topical application of the irritant, hyperplasiogenic and tumor-promoting phorbol ester 12-O- tetradecanoylphorbol-13-acetate (TPA) onto mouse skin in vivo, is a 50- to 150-fold increase of an enzyme activity converting arachidonic acid into 8-hydroxy-5Z, 9E, 11Z, 14Z-eicosatetraenoic acid (8- HETE) while the epidermal 12-lipoxygenase activity remained unaffected (2).

Keywords

HPLC EDTA Recombination Dimethyl Hull 

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • G. FüRstenberger
    • 1
  • T. Jacobi
    • 1
  • B. Schurich
    • 1
  • M. LöSchke
    • 1
  • W. D. Lehmann
    • 1
  • M. Stephan
    • 1
  • F. Marks
    • 1
  1. 1.Department of Biochemistry and Central Spectroscopy DepartmentGerman Cancer Research CenterHeidelbergGermany

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