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The Significance of the Peroxide Tone in the Arachidonic Acid Cascade

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury

Part of the book series: Developments in Oncology ((DION,volume 71))

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Abstract

There is good evidence from a number of cellular systems that the rate-limiting step of the arachidonic acid cascade consists in the release of arachidonate from phospholipids. At first sight, prostaglandin H synthase (PGHS) seems to be unrestricted under cellular conditions and the lipoxygenases although being partially dependent on Ca2+ are not limiting since phospholipase A2 requires Ca2+-levels that are higher than those for lipoxygenases as recently shown for leukotriene synthesis in leukocytes (1).

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References

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Author information

Authors and Affiliations

  1. Faculty of Biology, University of Konstanz, W-7750, Konstanz, Germany

    V. Ullrich, G. Hecker, F. Meisch & M. Schatz-Munding

Authors
  1. V. Ullrich
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  2. G. Hecker
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  3. F. Meisch
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  4. M. Schatz-Munding
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Editor information

Editors and Affiliations

  1. Department of Gynecological Endocrinology, Klinikum Steglitz, Free University Berlin, Berlin, Germany

    Santosh Nigam

  2. Department of Radiation Oncology, Wayne State University, Detroit, MI, USA

    Kenneth V. Honn

  3. Department of Biochemistry, Vanderbilt University, Nashville, TN, USA

    Lawrence J. Marnett

  4. Department of Radiation Biochemistry, Armed Forces Radiobiology Research Institute, Bethesda, MD, USA

    Thomas L. Walden Jr.

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© 1993 Springer Science+Business Media New York

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Ullrich, V., Hecker, G., Meisch, F., Schatz-Munding, M. (1993). The Significance of the Peroxide Tone in the Arachidonic Acid Cascade. In: Nigam, S., Honn, K.V., Marnett, L.J., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury. Developments in Oncology, vol 71. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3520-1_4

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  • DOI: https://doi.org/10.1007/978-1-4615-3520-1_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6562-4

  • Online ISBN: 978-1-4615-3520-1

  • eBook Packages: Springer Book Archive

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