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Cellular Phospholipases A2 in Inflammatory Processes

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury

Part of the book series: Developments in Oncology ((DION,volume 71))

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Abstract

Phospholipases A2 (PLA2) play an important role in immunoinflammatory processes (1). They are involved in the synthesis of lipid mediators in nearly all inflammatory cells (2). In addition, a 14 kD type II PLA2 exhibiting strong homologies with pancreatic type I PLA2 is secreted during inflammation (1). This secretion occurs from various cells and tissues: liver cells (3), mesangial cells (4), vascular smooth muscle cells (5) and astrocytes (6) in reponse to various cytokines (TNFα, IL1, IL6).

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Author information

Authors and Affiliations

  1. Departement de Biochimie (URA CNRS 1283), CHU Saint Antoine Universite, Paris VI, France

    R. Levistre, P. Pernas, J. Masliah & G. Béréziat

Authors
  1. R. Levistre
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  2. P. Pernas
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  3. J. Masliah
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  4. G. Béréziat
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Editor information

Editors and Affiliations

  1. Department of Gynecological Endocrinology, Klinikum Steglitz, Free University Berlin, Berlin, Germany

    Santosh Nigam

  2. Department of Radiation Oncology, Wayne State University, Detroit, MI, USA

    Kenneth V. Honn

  3. Department of Biochemistry, Vanderbilt University, Nashville, TN, USA

    Lawrence J. Marnett

  4. Department of Radiation Biochemistry, Armed Forces Radiobiology Research Institute, Bethesda, MD, USA

    Thomas L. Walden Jr.

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© 1993 Springer Science+Business Media New York

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Levistre, R., Pernas, P., Masliah, J., Béréziat, G. (1993). Cellular Phospholipases A2 in Inflammatory Processes. In: Nigam, S., Honn, K.V., Marnett, L.J., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury. Developments in Oncology, vol 71. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3520-1_38

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  • DOI: https://doi.org/10.1007/978-1-4615-3520-1_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6562-4

  • Online ISBN: 978-1-4615-3520-1

  • eBook Packages: Springer Book Archive

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