Advertisement

Modulatory Effects of PGD2-Analogue ZK 110 841 on Tumor Cell Proliferation

  • A. Zakrzewicz
  • S. Nigam
Part of the Developments in Oncology book series (DION, volume 71)

Abstract

Prostaglandin D2 has been reported to play an important role in bronchoconstriction (1), in the sleep-wake regulation (2) and in the inhibition of tumor cell proliferation in vitro (3). Since PGD2 is chemically relatively unstable and some of its metabolites possess substantial biological activity, several stable analogues of PGD2 have been developed. For instance, 9-Deoxy-9β-chloro-16,17,18,19,20- pentanor-15-cyclohexyl-PGF2 α (ZK 110 841) has been shown to mimic receptor-mediated PGD2 activity on human platelets, such as stimulation of adenylate cyclase, inhibition of thrombin-induced intracellular calcium [Ca2+] and ADP-induced platelet aggregation (4). ZK 110 841 has also been demonstrated to inhibit the proliferation of cultured human glioma cells (5) and antagonize the receptor-mediated PMN activation (6).

Keywords

HeLa Cell Tumor Cell Proliferation Human Glioma Cell Thymidine Uptake ASPC1 Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hardy, C.C., Robinson, C., Tattersfield, A.E. and Holgate, S.T. New England Journal of Medicine 311(4): 209–213, 1984.PubMedCrossRefGoogle Scholar
  2. 2.
    Hayaishi, O. The Journal of Biological Chemistry 263(29): 14593–14596, 1988.PubMedGoogle Scholar
  3. 3.
    Ito, S., Narumiya, S., Hayaishi, O. Prostaglandins Leukotrienes and Essential Fatty Acids. 37: 219–234, 1989.CrossRefGoogle Scholar
  4. 4.
    Thierauch, K.H., Sturzebecher, C.S. and Schillinger, E. Prostaglandins. 35(6): 855–868, 1988PubMedCrossRefGoogle Scholar
  5. 5.
    Westphal, M., Neuss, M., Herrmann, H.-D. Acta Neurochir (Wien). 83: 56–61, 1986.CrossRefGoogle Scholar
  6. 6.
    Ney, P., Schrör, K. Eicosanoids. 4: 21–28, 1991.PubMedGoogle Scholar
  7. 7.
    Ruiz-Arguelles, A., Llorente, L., Diaz-Jouanen, E., Alarcon-Segovia, D. Immunology. 44: 811–815, 1981.PubMedGoogle Scholar
  8. 8.
    Tsien, R.Y., Pozzan T., Rink, T.J. Nature. 295: 68–71, 1982.PubMedCrossRefGoogle Scholar
  9. 9.
    Grynkiewicz, G., Poenie, M., Tsien, R.Y. J. Biol. Chem. 260: 3440–3450, 1985.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • A. Zakrzewicz
    • 1
  • S. Nigam
    • 1
  1. 1.Eicosanoid Research, Dept. of Gynecology, Klinikum SteglitzFree University BerlinBerlin 45Germany

Personalised recommendations