Modulatory Effects of PGD2-Analogue ZK 110 841 on Tumor Cell Proliferation

  • A. Zakrzewicz
  • S. Nigam
Part of the Developments in Oncology book series (DION, volume 71)


Prostaglandin D2 has been reported to play an important role in bronchoconstriction (1), in the sleep-wake regulation (2) and in the inhibition of tumor cell proliferation in vitro (3). Since PGD2 is chemically relatively unstable and some of its metabolites possess substantial biological activity, several stable analogues of PGD2 have been developed. For instance, 9-Deoxy-9β-chloro-16,17,18,19,20- pentanor-15-cyclohexyl-PGF2 α (ZK 110 841) has been shown to mimic receptor-mediated PGD2 activity on human platelets, such as stimulation of adenylate cyclase, inhibition of thrombin-induced intracellular calcium [Ca2+] and ADP-induced platelet aggregation (4). ZK 110 841 has also been demonstrated to inhibit the proliferation of cultured human glioma cells (5) and antagonize the receptor-mediated PMN activation (6).


HeLa Cell Tumor Cell Proliferation Human Glioma Cell Thymidine Uptake ASPC1 Cell 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • A. Zakrzewicz
    • 1
  • S. Nigam
    • 1
  1. 1.Eicosanoid Research, Dept. of Gynecology, Klinikum SteglitzFree University BerlinBerlin 45Germany

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