Modulatory Effects of PGD2-Analogue ZK 110 841 on Tumor Cell Proliferation
Prostaglandin D2 has been reported to play an important role in bronchoconstriction (1), in the sleep-wake regulation (2) and in the inhibition of tumor cell proliferation in vitro (3). Since PGD2 is chemically relatively unstable and some of its metabolites possess substantial biological activity, several stable analogues of PGD2 have been developed. For instance, 9-Deoxy-9β-chloro-16,17,18,19,20- pentanor-15-cyclohexyl-PGF2 α (ZK 110 841) has been shown to mimic receptor-mediated PGD2 activity on human platelets, such as stimulation of adenylate cyclase, inhibition of thrombin-induced intracellular calcium [Ca2+] and ADP-induced platelet aggregation (4). ZK 110 841 has also been demonstrated to inhibit the proliferation of cultured human glioma cells (5) and antagonize the receptor-mediated PMN activation (6).
KeywordsProstaglandin Verapamil Thymidine Eicosanoid Staurosporine
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