A monocentric therapy study: An approach to optimize the results of the treatment of osteosarcoma by protocols based upon HDMTX, associated with systematic conservative surgery

  • N. Delepine
  • G. Delepine
  • J. C. Desbois
Part of the Cancer Treatment and Research book series (CTAR, volume 62)


In order to understand why Rosen’s protocol [1] has not been reproduced by most groups [2, 3, 4, 5] that used the same scheme, we started preliminary study in 1984 using T10 to analyze methotrexate (MTX) pharmacokinetics and its correlations with clinical and histological results. From 1985 to 1989 a second pilot study was conducted to optimize the results of Rosen while conducting a pharmacokinetic analysis to understand the reasons for failures in attempts to reproduce T10 and to emphasize the fundamental points for curing osteosarcomas.


Preoperative Chemotherapy Poor Responder Good Responder Therapeutic Intensity Folinic Acid Rescue 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • N. Delepine
    • 1
  • G. Delepine
  • J. C. Desbois
    • 2
  1. 1.Oncologic Pediatric ServiceUniversity Hospital Robert DebreParisFrance
  2. 2.Pre-Gentil ClinicRosnyFrance

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