In vivo 31P nuclear magnetic resonance spectroscopy of osteosarcoma
Characterization of tumor processes and studying their metabolism is one of the main challenges in diagnostic clinical oncology. Magnetic resonance spectroscopy (MRS) provides a noninvasive method to monitor tissue metabolism. Since the early work of Griffiths , an increasing number of papers have been published on in vivo measurement of tumor metabolism using MRS. Detailed accounts of the methods of NMR spectroscopy and NMR imaging have been published [2,3] and are beyond the scope of this review.
KeywordsMagnetic Resonance Spectroscopy Soft Tissue Tumor Tumor Metabolism Tumor Spectrum Bone Marrow Disease
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- 1.Griffiths JR, Cady E, Edwards RTH, et al. 31-P NMR studies of a human tumor in situ (letter). Lancet 1:1435–1436, 19.Google Scholar
- 2.Koutcher JA, Burt CT. Principles of nuclear magnetic resonance. J. Nuclear Med 25:101–111, 1984.Google Scholar
- 4.Gadian DG. Nuclear Magnetic Resonance and its Applications to Living Systems. Oxford University Press, New York, 1982.Google Scholar
- 6.Daly PF, Lyon RC, Faustino PJ, Cohen JS. Phospholipid metabolism in cancer cells monitored by 31P NMR spectroscopy. J. Biol Chem 262:2596–2604, 1987.Google Scholar
- 13.Boeve WJ, Kamman RL, Mooyaart EL, et al. In vivo phosphorous magnetic resonance spectroscopy of bone and soft tissue tumors. In 8th Annual Meeting of the Society of MRM. Book of Abstracts, 549, 1989.Google Scholar
- 14.Boeve WJ, Hoekstra HJ, Kamman RL, et al. The clinical value of in vivo 31-phosphorous magnetic resonance spectroscopy (MRS) of bone and soft tissue tumors. Am Soc Clin Oncol, 1991.Google Scholar