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Diffusion of methotrexate from surgical acrylic cement

  • P. Hernigou
  • B. Brun
  • A. Astier
  • D. Goutallier
  • J. P. le Bourgeois
Part of the Cancer Treatment and Research book series (CTAR, volume 62)

Abstract

There are two causes of failure in the surgical treatment of bone tumors. One is local recurrence of the tumor, which is not always avoidable, even after wide surgical excision and systemic chemotherapy. The other is difficulty in controlling metastases after surgical treatment. For these reasons, chemotherapy treatment is now recommended preoperatively, and it is continued as soon as possible after definitive surgery but not, in theory, before skin healing has taken place. To limit the postoperative period with chemotherapy, we thought that it would be interesting to apply perioperative and immediate postoperative chemotherapy by adding an antimitotic agent to the acrylic cement used to fill the loss of bone substance or to fix reconstructive prostheses, as is already done with many antibiotics, which would diffuse into the surrounding tissues.

Keywords

Bone Tumor Bone Cement Limb Salvage Spinal Metastasis Pharmacological Data 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Hernigou P, Thiery JP, Benoit J, et al. Release of antimitotic drugs from acrylic cement and plaster. Eur Surg Res 19(Suppl 1):25, 1987.Google Scholar
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    Hernigou P, Thiery JP, Benoist M, et al. Etude expérimentale sur l’ostéosarcome d’une chimiothérapie locale diffusant à partir de ciment acrylique chirurgical et de plâtre. Rev Chir Orthop 73:517–525, 1987.PubMedGoogle Scholar
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    Hernigou P, Thiery JP, Benoit, J. et al. Diffusion of methotrexate from surgical acrylic cement. Bone Joint Surg [Br] 71B:804–811, 1989.Google Scholar
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • P. Hernigou
    • 1
  • B. Brun
    • 2
  • A. Astier
    • 3
  • D. Goutallier
    • 1
  • J. P. le Bourgeois
    • 2
  1. 1.Department of Orthopaedic SurgeryHopital Henri MondorCreteilFrance
  2. 2.Department of OncologyHopital Henri MondorCreteilFrance
  3. 3.Department of PharmacologyHopital Henri MondorCreteilFrance

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