Diffusion of methotrexate from surgical acrylic cement
There are two causes of failure in the surgical treatment of bone tumors. One is local recurrence of the tumor, which is not always avoidable, even after wide surgical excision and systemic chemotherapy. The other is difficulty in controlling metastases after surgical treatment. For these reasons, chemotherapy treatment is now recommended preoperatively, and it is continued as soon as possible after definitive surgery but not, in theory, before skin healing has taken place. To limit the postoperative period with chemotherapy, we thought that it would be interesting to apply perioperative and immediate postoperative chemotherapy by adding an antimitotic agent to the acrylic cement used to fill the loss of bone substance or to fix reconstructive prostheses, as is already done with many antibiotics, which would diffuse into the surrounding tissues.
KeywordsToxicity Creatinine Anemia Methotrexate Osteosarcoma
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