Histologic subclassification of osteosarcoma: Differential diagnostic problems and immunohistochemical aspects

  • Shinichiro Ushigome
  • Kazuhito Nakamori
  • Takashi Nikaido
  • Masayuki Takagi
Part of the Cancer Treatment and Research book series (CTAR, volume 62)


Histologic subclassification of osteosarcoma, with the exception of parosteal osteosarcoma [1, 2, 3], has not been regarded to be useful as a prognostic parameter. Nevertheless, it is now applied in routine surgical pathology. A generally accepted subclassification is the one by Dahlin and Unni of the Mayo Clinic [4,5] (Table16-1). Our experience is shown in Table 16-2. MFH-mimicking osteosarcoma, giant-cell-rich osteosarcoma, and dedifferentiation of intraosseous well-differentiated osteosarcoma are added.


Malignant Fibrous Histiocytoma Giant Cell Tumor Aneurysmal Bone Cyst Parosteal Osteosarcoma Conventional Osteosarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Shinichiro Ushigome
    • 1
  • Kazuhito Nakamori
    • 1
  • Takashi Nikaido
    • 1
  • Masayuki Takagi
    • 2
  1. 1.Department of PathologyJikei University School of MedicineTokyo 105Japan
  2. 2.Department of PathologySt. Marianna School of MedicineKawasaki-shi 213Japan

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