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Abnormal Mitochondrial Oxidative Phosphorylation of Ischaemic and Reperfused Myocardium Reversed by L-Propionyl-Carnitine

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Cardiovascular Disease in Diabetes

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 130))

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Abstract

In the experimental animal, L-propionyl-carnitine, one of the most potent analogues of carnitine (1,2,3) exert a cardioprotective action on ischaemic and reperfused myocardium (4,5,6,7). Despite considerable efforts to find explanation for these beneficial effects, a commonly accepted basic mechanism is still lacking. Recently it has been suggested that L-propionyl-carnitine protects the ischaemic myocardium by improving mitochondrial function (7,8,9). We now describe the effect of L-propionyl-carnitine on the deterioration on mitochondrial function caused by ischaemia and reperfusion in the isolated rabbit hearts. L-propionyl-carnitine was used at the concentration of 10-7 M, as it has been shown to be an optimal dose for cardioprotection (9). Some of the present data have been published (6,9).

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Authors and Affiliations

  1. Departments of Cardiology and Chemistry, University of Brescia, Brescia, Italy

    R. Ferrari, E. Pasini, A. Cargnoni, E. Condorelli, F. De Giuli & A. Albertini

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  1. R. Ferrari
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  2. E. Pasini
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  3. A. Cargnoni
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  4. E. Condorelli
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  5. F. De Giuli
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  6. A. Albertini
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

    Makoto Nagano  & Seibu Mochizuki  & 

  2. Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla

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© 1992 Springer Science+Business Media New York

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Ferrari, R., Pasini, E., Cargnoni, A., Condorelli, E., De Giuli, F., Albertini, A. (1992). Abnormal Mitochondrial Oxidative Phosphorylation of Ischaemic and Reperfused Myocardium Reversed by L-Propionyl-Carnitine. In: Nagano, M., Mochizuki, S., Dhalla, N.S. (eds) Cardiovascular Disease in Diabetes. Developments in Cardiovascular Medicine, vol 130. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3512-6_32

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  • DOI: https://doi.org/10.1007/978-1-4615-3512-6_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6558-7

  • Online ISBN: 978-1-4615-3512-6

  • eBook Packages: Springer Book Archive

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