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Radionuclide Assessment of Left Ventricular Function in Middle-Aged Asymptomatic Non-Insulin-Dependent Diabetic Patients

  • I. Yasuda
  • K. Kawakami
  • T. Shimada
  • K. Tanigawa
  • R. Murakami
  • S. Izumi
  • S. Morioka
  • Y. Kato
  • K. Moriyama
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 130)

Abstract

The incidence of congestive heart failure is increased in patients with diabetes mellitus (1,2,3) and there is evidence that cardiac dysfunction occurs in diabetic patients with normal coronary arteries (4,5), but the causes of these abnormalities are still unclarified. Some authors (6,7) have suggested the existence of a specific diabetic cardiomyopathy. Rubler et al. (6) reported four adult-onset diabetic patients who had cardiomegaly and congestive heart failure in the absence of major coronary artery disease or hypertension. Hamby et al. (7) observed a high incidence of diabetes mellitus in their series of patients with idiopathic cardiomyopathy. On the other hand, it has been proposed that metabolic derangements of diabetes may impair the left ventricular function (4,8). Several investigators have shown that abnormalities of left ventricular systolic (9–14) or diastolic (4,8,15–17) function or both (18,19) are common in diabetics even without coronary artery disease and clinical manifestations of congestive heart failure. Abnormalities of the left ventricular function have been shown in diabetic patients at rest (4,9,20,21) and also during exercise (10-14). Whether these abnormalities result either from microangiopathy in the heart or from metabolic derangements inherent to diabetes mellitus remains unclear.

Keywords

Left Ventricular Ejection Fraction Diabetic Group Peak Filling Rate Radionuclide Ventriculography Total Workload 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • I. Yasuda
    • 1
  • K. Kawakami
    • 1
  • T. Shimada
    • 1
  • K. Tanigawa
    • 1
  • R. Murakami
    • 1
  • S. Izumi
    • 1
  • S. Morioka
    • 1
  • Y. Kato
    • 1
  • K. Moriyama
    • 1
  1. 1.Departments of Internal MedicineShimane Medical UniversityIzumoJapan

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