Radionuclide Assessment of Left Ventricular Function in Middle-Aged Asymptomatic Non-Insulin-Dependent Diabetic Patients
The incidence of congestive heart failure is increased in patients with diabetes mellitus (1,2,3) and there is evidence that cardiac dysfunction occurs in diabetic patients with normal coronary arteries (4,5), but the causes of these abnormalities are still unclarified. Some authors (6,7) have suggested the existence of a specific diabetic cardiomyopathy. Rubler et al. (6) reported four adult-onset diabetic patients who had cardiomegaly and congestive heart failure in the absence of major coronary artery disease or hypertension. Hamby et al. (7) observed a high incidence of diabetes mellitus in their series of patients with idiopathic cardiomyopathy. On the other hand, it has been proposed that metabolic derangements of diabetes may impair the left ventricular function (4,8). Several investigators have shown that abnormalities of left ventricular systolic (9–14) or diastolic (4,8,15–17) function or both (18,19) are common in diabetics even without coronary artery disease and clinical manifestations of congestive heart failure. Abnormalities of the left ventricular function have been shown in diabetic patients at rest (4,9,20,21) and also during exercise (10-14). Whether these abnormalities result either from microangiopathy in the heart or from metabolic derangements inherent to diabetes mellitus remains unclear.
KeywordsLeft Ventricular Ejection Fraction Diabetic Group Peak Filling Rate Radionuclide Ventriculography Total Workload
Unable to display preview. Download preview PDF.
- 12.Margonato A, Gerundini P, Vicedomini G, Gilardi MC, Pozza G, Fazio F. Abnormal cardiovascular response to exercise in young asymptomatic diabetic patients with retinopathy. Am Heart J 1986; Am Heart J 1986;112:554–560.Google Scholar
- 14.Mustonen JN, Uusitupa MIJ. Tahvaninen K, Tarwar S, Laakso M, Lansimies E, KuiKKa JT, Pyorala K. Impaired left ventricular systolic function during exercise in middle-aged insulin-dependent and noninsulindependent diabetic subjects without clinically evident cardiovascular disease. Am J Cardiol 1988;62:1273–1279.PubMedCrossRefGoogle Scholar
- 22.Gorcia MJ, McNamara PM, Gordon T, Kannel WB. Morbiditiy and mortality in diabetics in the Framingham population. Diabetes 1974;23:105–111.Google Scholar
- 27.Ledet T. Diabetic cardiopathy: quantitative histologic studies of the heart from young juvenile diabetes. Acta Pathol Microbiol Scand (A) 1976;84:421–428.Google Scholar