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Insulin-Like Actions of Vanadyl Sulfate Trihydrate in Streptozotocin-Diabetic Rats

  • Chapter
Cardiovascular Disease in Diabetes

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 130))

  • 44 Accesses

Abstract

Vanadium is a ubiquitous group V transitional element (atomic weight 50.94). An essential trace nutrient in chicks, dietary deficiencies were observed to result in decreased body and feather growth although in rats, impaired reproductive ability, the sole consequence of vanadium lack is seen only after four generations (1). In humans, the total vanadium pool is estimated to range between 100–200 ug although symptoms of deficiency have not yet been established (2). Vanadium exists in several valence forms (-1 to +5) and in red blood cells and adipocytes is converted intracellularly from vanadate (V03-,+5) to vanadyl (V02+,+4) (3).

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Author information

Authors and Affiliations

  1. Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, B.C., V6T 1W5, Canada

    Margaret C. Cam & John H. McNeill

Authors
  1. Margaret C. Cam
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  2. John H. McNeill
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Editors and Affiliations

  1. Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

    Makoto Nagano  & Seibu Mochizuki  & 

  2. Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla

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© 1992 Springer Science+Business Media New York

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Cam, M.C., McNeill, J.H. (1992). Insulin-Like Actions of Vanadyl Sulfate Trihydrate in Streptozotocin-Diabetic Rats. In: Nagano, M., Mochizuki, S., Dhalla, N.S. (eds) Cardiovascular Disease in Diabetes. Developments in Cardiovascular Medicine, vol 130. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3512-6_28

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  • DOI: https://doi.org/10.1007/978-1-4615-3512-6_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6558-7

  • Online ISBN: 978-1-4615-3512-6

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