Electron Microscopic Cytochemical Studies on ATPase and Acid Phosphatase Activities of Cardiac Myocytes in Streptozotocin Induced Diabetic Rats
It has often been reported that a crisis of congestive heart failure is frequently observed in patients with diabetes mellitus independent of coronary artery disease or hypertension (1). In this respect, a contraction/relaxation disorder of the cardiac muscle has also been noted in animal experiments. The dysfunction of the heart observed in diabetes is known as so-called diabetic cardiomyopathy (2). However for its causes, while complex factors such as intramyocardial microangiopathy and myocardial metabolic disorder caused by diabetes are suspected, a definitive conclusion has not yet been drawn.
KeywordsATPase Activity Sarcoplasmic Reticulum Myocardial Cell Acid Phosphatase Activity Diabetic Cardiomyopathy
Unable to display preview. Download preview PDF.
- 6.Seager MJ, Singal PK, Orchard R, Pierce GN and Dhalla NS. Cardiac cell damage: A primary myocardial disease in streptozotocin-induced chronic diabetes. Br J Exp Path 1984;65:613–623.Google Scholar
- 7.Factor SM, Minase T, Bhan R, Wolinsky H and Sonnenblick EH. Hypertensive diabetic cardiomyopathy in the rat: Ultrastructural features. Pathol Anat 1983;398:305–317.Google Scholar
- 11.Hisao Y, Suzuki K, Abe H and Toyota T. Ultrastructural alterations in cardiac muscle of diabetic BB Wistar rats. Pathol Anat 1987;411:45–52.Google Scholar
- 14.Yaida M, Umezawa Y, Konno N and Katagiri T. Alterations in cardiac sarcoplasmic reticulum and structural proteins in streptozotocin-induced diabetic rats. J Showa Med 1988;48(2):175–182.Google Scholar
- 16.Gomori G. An improved histochemical technique for acid phosphatase. Stain Tech 1950;25:81–85.Google Scholar
- 18.Nakamura N, Sasai Y, Takeyama Y and Katagiri T. Electron microscopic cytochemical studies on acid phosphatase activity in acute myocardial ischemia. Jpn Circ J 1983;24:595–606.Google Scholar
- 19.Vtyurin BV. Concerning the structure and function of lysosomes. Arkh Pathol 1968;30:51–56.Google Scholar
- 25.Ledet T. Diabetic cardiomyopathy. Quantitative histological studies of the heart from young juvenile diabetics. Acta Pathol Microbiol Scand Sect A 1976;84:421–428.Google Scholar
- 27.Ganguly PK, Pierce GN, Dhalla KS and Dhalla NS. Defective sarcoplasmic reticular calcium transport in diabetic cardiomyopathy. Am J Cardiol 1983;244:E528-E535.Google Scholar