Electron Microscopic Cytochemical Studies on ATPase and Acid Phosphatase Activities of Cardiac Myocytes in Streptozotocin Induced Diabetic Rats

  • Y. Suwa
  • Y. Umezawa
  • M. Yaida
  • Y. Takeyama
  • T. Katagiri
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 130)


It has often been reported that a crisis of congestive heart failure is frequently observed in patients with diabetes mellitus independent of coronary artery disease or hypertension (1). In this respect, a contraction/relaxation disorder of the cardiac muscle has also been noted in animal experiments. The dysfunction of the heart observed in diabetes is known as so-called diabetic cardiomyopathy (2). However for its causes, while complex factors such as intramyocardial microangiopathy and myocardial metabolic disorder caused by diabetes are suspected, a definitive conclusion has not yet been drawn.


ATPase Activity Sarcoplasmic Reticulum Myocardial Cell Acid Phosphatase Activity Diabetic Cardiomyopathy 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Y. Suwa
    • 1
  • Y. Umezawa
    • 1
  • M. Yaida
    • 1
  • Y. Takeyama
    • 1
  • T. Katagiri
    • 1
  1. 1.Third Department of Internal MedicineShowa University School of MedicineTokyoJapan

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