Biochemical and Morphologic Alterations in Cardiac Myocytes in Streptozotocin-Induced Diabetic Rats
Complication of congestive heart failure in patients with diabetes mellitus has well been known in clinical practice. Impairment of cardiac function was recognized in the absence of arteriosclerotic changes in diabetics, and the concept of “diabetic cardiomyopathy” has been proposed as the diabetes specific myocardial disorder (1,2). In the clinical practice, diabetes mellitus occurs in the mature to elder age and complication of coronary arterio- or athero-sclerosis is usual. Therefore, influence of ischemia could not be excluded in clinical cases. To elucidate effect of hyperglycemic state on cardiac myocytes without vascular changes, experimental diabetes was induced in relatively young rats by single intravenous injection of streptozotocin (STZ), and the effects of abrupt and long-standing severe hyperglycemia on the cardiac micro organs such as the sarcoplasmic reticulum (SR) and the structural proteins were investigated in comparison with the fine structures of cardiac myocytes.
KeywordsATPase Activity Diabetic Cardiomyopathy Diabetic Heart Sarcoplasmic Reticulum Membrane Terminal Cisterna
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