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Combined Effects of Hypertension and Diabetes on Myocardial Contractile Proteins and Cardiac Function in Rats

  • M. Kato
  • N. Takeda
  • E. Kazama
  • J. Yang
  • T. Asano
  • H. Q. Yin
  • M. Nagano
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 130)

Abstract

Hypertension occurs with greater frequency in diabetic than in non- diabetic patients, and when heart failure develops in these patients it is occasionally resistant to therapy. Clinically, numerous reports have indicated a close relationship between diabetes and hypertension. Hypertension and diabetes mellitus (DM) both show a wide prevalence in humans; they can cause a number of myocardial deficiencies, resulting in a strikingly increased incidence of heart failure. The present study investigated the influence of hypertension, diabetes, and their combination on cardiac function and cardiac contractile proteins in Wistar rats.

Keywords

ATPase Activity Alloxan Diabetes Myofibrillar ATPase Activity Blood Pressure Curve Myosin Isoenzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • M. Kato
    • 1
  • N. Takeda
    • 1
  • E. Kazama
    • 1
  • J. Yang
    • 1
  • T. Asano
    • 1
  • H. Q. Yin
    • 1
  • M. Nagano
    • 1
  1. 1.Department of Internal Medicine, Aoto HospitalJikei University School of MedicineKatsushika-ku, TokyoJapan

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