Combined Effects of Hypertension and Diabetes on Myocardial Contractile Proteins and Cardiac Function in Rats

  • M. Kato
  • N. Takeda
  • E. Kazama
  • J. Yang
  • T. Asano
  • H. Q. Yin
  • M. Nagano
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 130)


Hypertension occurs with greater frequency in diabetic than in non- diabetic patients, and when heart failure develops in these patients it is occasionally resistant to therapy. Clinically, numerous reports have indicated a close relationship between diabetes and hypertension. Hypertension and diabetes mellitus (DM) both show a wide prevalence in humans; they can cause a number of myocardial deficiencies, resulting in a strikingly increased incidence of heart failure. The present study investigated the influence of hypertension, diabetes, and their combination on cardiac function and cardiac contractile proteins in Wistar rats.


ATPase Activity Alloxan Diabetes Myofibrillar ATPase Activity Blood Pressure Curve Myosin Isoenzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kaplan NM. The Goldblatt Memorial Lecture, Part II. The role of the kidney in hypertension. Hypertension 1979;1:456–461.PubMedCrossRefGoogle Scholar
  2. 2.
    Stracher A. Evidence for the involvement of light chains in the biological functioning of myosin. Biochem Biophys Res Commun 1969;35:519–525.PubMedCrossRefGoogle Scholar
  3. 3.
    Medugorac I. Characteristics of the hypertrophied left ventricular myocardium in Goldblatt rats. Basic Res Cardiol 1977;72:261–267.PubMedCrossRefGoogle Scholar
  4. 4.
    Hoh JFY, McGrath PA and Hale PT. Electrophoretic analysis of multiple forms of rat cardiac myosin: Effects of hypophysectomy and thyroxine replacement. J Mol Cell Cardiol 1977; 10:1053–1076.CrossRefGoogle Scholar
  5. 5.
    Dowel RT, Cutilletta AF and Sodt PC. Functional evaluation of the rat heart in situ. J Appl Physiol 1975;39:1043–1047Google Scholar
  6. 6.
    Fein FS, Cho S, Zola BE, Miller B and Factor SM. Cardiac pathology in the hypertensive diabetic rat. Biventricular damage with right ventricular predominance. Am J Pathol 1989;134:1159–1166-PubMedGoogle Scholar
  7. 7.
    Factor SM, Minase T, Cho S, Fein F, Capasso JM and Sonnenblick EH. Coronary microvascular abnormalities in the hypertensive-diabetic rat. A primary case of cardiomyopathy? Am J Pathol 1984;116:9–20.Google Scholar
  8. 8.
    Fein FS, Capasso JM, Aronson RS, Cho S, Nordin C, Miller-Green B, Sonnenblick EH and Factor SM. Combined renovascular hypertension and diabetes in rats: A new preparation of congestive cardiomyopathy. Circulation 1984;70:318–330.PubMedCrossRefGoogle Scholar
  9. 9.
    Factor SM, Bhan R, Minase T, Wolinsky H and Sonnenblick EH. Hypertensive-diabetic cardiomyopathy in the rat. An experimental model of human disease. Am J Pathol 1981; 102:218–228.Google Scholar
  10. 10.
    Mall G, Klingel K, Baust H, Hasslacher Ch, Mann J, Mattfeldt T and Waldherr R. Synergistic effects of diabetes mellitus and renovascular hypertension on the rat heart-stereological investigations on papillary muscles. Virchows Arch A 1987;411:531–542.CrossRefGoogle Scholar
  11. 11.
    Rodgers RL. Depressor effect of diabetes in the spontaneously hypertensive rat: Associated changes in heart performance. Can J Physiol Pharmacol 1985;64:1177–1184.CrossRefGoogle Scholar
  12. 12.
    Takeda N, Nakamura I, Hatanaka T, Ohkubo T. and Nagano M. Myocardial mechanical and myosin isoenzyme alterations in streptozotocin-diabetic rats. Jap Heart J 1988;29:455–463.PubMedCrossRefGoogle Scholar
  13. 13.
    Rupp H, Kissling G and Jocob R. Hormonal and hemodynamic determinants of polymorphic myosin. In: Perspectives in Cardiovascular Research, Vol. 7. Katz, AM (ed). Raven Press, New York, 1983, pp.373–383.Google Scholar
  14. 14.
    Schwartz K, Lompre AM, Lacombe G, Bouveret P, Wisnewsky C, Whalen RG, D’Albis A and Swynghedauw B. Cardiac myosin isoenzymic transitions in mammals. In: Perspectives in Cardiovascular Research, Vol 7. Katz, AM (ed). Raven Press, New York, 1983, pp.345–358.Google Scholar
  15. 15.
    Carey RA, Natarajan G, Bove AA, Coulson RL and Spann JF. Myosin adenosine triphosphatase activity in the volume-overloaded hypertrophied feline right ventricle. Circ Res 1979;45:81–87.PubMedCrossRefGoogle Scholar
  16. 16.
    Scheuer J and Bahn AK. Cardiac contractile proteins. Adenosine triphosphatase activity and physiological function. Circ Res 1978;45:1–12.CrossRefGoogle Scholar
  17. 17.
    Fein FS, Kornstein LB, Strobeck JE, Capasso JM and Sonnenblick EH. Altered myocardial mechanics in diabetic rats. Circ Res 1980;47:922–933.PubMedCrossRefGoogle Scholar
  18. 18.
    Pierce GN and Dhalla NS. Cardiac myofibrillar ATPase activity in diabetic rats. J Mol Cell Cardiol 1981; 13:1063–1069.PubMedCrossRefGoogle Scholar
  19. 19.
    Takeda N, Nakamura I, Ohkubo T, Hatanaka T and Nagano M. Effects of physical training on the myocardium of streptozotocin-induced diabetic rats. Basic Res Cardiol 1988;83:525–530.PubMedCrossRefGoogle Scholar
  20. 20.
    Jacob R, Ebrecht G, Holubarsch CH, Rupp H and Kissling G. Mechanics and energetics in cardiac hypertrophy as related to the isoenzyme pattern of myosin. Perspectives in Cardiovascular Research, Vol. 7. Katz, AM. (ed.) Raven Press, New York, 1983, pp. 553–569.Google Scholar
  21. 21.
    Spech MM, Ferrario CM and Tarazi RC. Cardiac pumping ability following reversal of hypertrophy and hypertension in spontaneously hypertensive rats. Hypertension 1980;2:75–82.PubMedCrossRefGoogle Scholar
  22. 22.
    Pfeffer JM, Pfeffer MA and Braunwald E. Development of left ventricular dysfunction in the female spontaneously hypertensive rats. In: Perspectives in Cardiovascular Research, Vol. 7. Katz, AM. (ed.) Raven Press, New York, 1983, pp.73–84.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • M. Kato
    • 1
  • N. Takeda
    • 1
  • E. Kazama
    • 1
  • J. Yang
    • 1
  • T. Asano
    • 1
  • H. Q. Yin
    • 1
  • M. Nagano
    • 1
  1. 1.Department of Internal Medicine, Aoto HospitalJikei University School of MedicineKatsushika-ku, TokyoJapan

Personalised recommendations