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The role of radiotherapy following radical prostatectomy

  • Michael K. Brawer
Part of the Cancer Treatment and Research book series (CTAR, volume 59)

Abstract

Adenocarcinoma of the prostate is currently the number one malignancy in men in the United States and the second most common cause of cancer-related deaths [1]. In part because of these sobering statistics, there has been increasing interest in curative therapy. Radical prostatectomy is emerging as the preferred therapeutic approach for a number of reasons. If neoplasm is organ confined, surgical extirpation offers the best chance of cure. Moreover, increasing evidence suggests that definitive radiation therapy is rarely able to sterilize the prostate [2]. Finally, technical advances have made radical retropubic prostatectomy more acceptable because of decreased morbidity.

Keywords

Radical Prostatectomy Digital Rectal Examination Transrectal Ultrasound Radical Retropubic Prostatectomy Seminal Vesicle Invasion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Silverberg E, Lubera JA: Cancer Statistics CA39:3–20.Google Scholar
  2. 2.
    Kabalin JN, Hodge K, McNeal JE, et al.: Identification of residual cancer in the prostate following radiation therapy: Role of transrectal ultrasound guided biopsy and prostate specific antigen. J Urol 142:326–331, 1989.PubMedGoogle Scholar
  3. 3.
    Lange PH, Narayan P: Understaging and undergrading of prostate cancer. Urology 21: 113–118, 1983.PubMedCrossRefGoogle Scholar
  4. 4.
    Catalona WJ, Stein AJ: Staging errors in clinically localized prostatic cancer. J Urol127:452–456.Google Scholar
  5. 5.
    Veenema RJ, Gursel EO, Lattimer JK: Radical retropubic prostatectomy for cancer: A 20-year experience. J Urol117:330–331, 1977.PubMedGoogle Scholar
  6. 6.
    Jewett HJ: The case for radical perineal prostatectomy. J Urol 103:195–199, 1970.PubMedGoogle Scholar
  7. 7.
    Gibbons RP, Correa RJ Jr., Brannen GE, Weissman RM: Total prostatectomy for clinically localized prostatic cancer: Long-term results. J Urol 141:564–566, 1989.PubMedGoogle Scholar
  8. 8.
    Elder JS, Jewett JH, Walsh PC: Radical perineal prostatectomy for clinical stage B2 carcinoma of the prostate. J Urol127:704–706, 1982.PubMedGoogle Scholar
  9. 9.
    Spigelman S, McNeal JE, Freiha FS, et al.: Rectal examination in volume determination of carcinoma of the prostate: Clinical and anatomical correlations. J Urol136:1228–1230, 1986.PubMedGoogle Scholar
  10. 10.
    Carter St. C, Talley D, Egawa S, et al.: Accurate preoperative determination of prostate cancer volume in clinically localized disease. J Urol 141:276A, 1989.Google Scholar
  11. 11.
    Denis L, Appel L, Broos J, et al.: Evaluation of prostatic cancer by transrectal ultra-sonography and CT scan. Acta Urol Belg 48:71, 1980.PubMedGoogle Scholar
  12. 12.
    Peeling WB, Griffiths GJ: Imaging of the prostate by ultrasound. J Urol132:217, 1984.PubMedGoogle Scholar
  13. 13.
    Pontes E, Ohe H, Watanabe H, et al.: Transrectal ultrasonography of the prostate. Cancer 53:1369, 1984.PubMedCrossRefGoogle Scholar
  14. 14.
    Resnick MI, Willard JW, Boyce WH: Transrectal ultrasonography in the evaluation of patients with prostatic cancer. J Urol 124:226–234, 1980.Google Scholar
  15. 15.
    Lee F: Transrectal ultrasound: Diagnosis and staging of prostatic carcinoma. Urology 33 (Suppl.):5–10, 1989.PubMedCrossRefGoogle Scholar
  16. 16.
    Stamey TA, McNeal JE, Freiha FS: Morphometric and clinical studies in 68 consecutive radical prostatecomies. J Urol139:1235, 1988.PubMedGoogle Scholar
  17. 17.
    Lange PH, Moon TD, Narayan P, et al.: Radiation treatment after radical prostatectomy: Patients’ tolerance and preliminary results. J Urol 136:45–49, 1986.PubMedGoogle Scholar
  18. 18.
    McNeal JE, Bostwick DG, Kindrachukra, et al.: Patterns of progression in prostatic cancer. Lancet 1:60–63, 1980.Google Scholar
  19. 19.
    Middleton RG, Smith JA Jr., Melzer RM, et al.: Patient survival local recurrence rate following radical prostatectomy following prostatic carcinoma. J Urol136:422–424, 1986.PubMedGoogle Scholar
  20. 20.
    Villers A, McNeal JE, Redwine EA, Freiha FS, Stamey TA: The role of perineural space invasion in the local spread of prostatic adenocarcinoma. J Urol 142:763–768, 1989.PubMedGoogle Scholar
  21. 21.
    Epstein J: Radical prostatectomy, capsular margins in the margins of resections: The significance of margins designated as negative equivocal and positive. J Urol 143:314A, 1990.Google Scholar
  22. 22.
    Lange PH, Lightner DJ, Medini E, Reddy PK: The effects of radiation therapy after radical prostatectomy in patients with elevated PSA levels J Urol, in press.Google Scholar
  23. 23.
    Lange PH, Ercole CJ, Lightner DJ, Fraley EE, Vessella R: The value of serum prostate specific antigen determinations before and after radical prostatectomy. J Urol 141:873–879, 1989.PubMedGoogle Scholar
  24. 24.
    Hudson MA, Bahnson RB, Catalona WJ: Clinical use of prostate specific antigen in patients with prostate cancer. J Urol, in press.Google Scholar
  25. 25.
    Culp OS: Radical perineal prostatectomy: Its past, present and possible future. J Urol 98:618–626, 1968.Google Scholar
  26. 26.
    Walsh PC, Jewett HJ: Radical surgery for prostatic cancer. Cancer 45:1906–1911.Google Scholar
  27. 27.
    Tomlinson RL, Currie DP, Boyce WH: Radical prostatectomy: Palliation for stage C carcinoma of the prostate. J Urol 117:85–87.Google Scholar
  28. 28.
    Robey EL, Schellhammer PF: Local failure after definitive therapy for prostatic cancer. J Urol 137:613–619.Google Scholar
  29. 29.
    Catalona WJ, Miller DR, Kavoussi LR: Intermediate-term survival results in clinically understaged prostate cancer patients following radical prostatectomy. J Urol 140:540–543.Google Scholar
  30. 30.
    Zincke H, Utz DC, Taylor WF: Bilateral pelvic lymphadenectomy and radical prostatectomy for clinical stage C prostatic cancer: Role of adjuvant treatment for residual cancer and in disease progression. J Urol 135:1199–1205.Google Scholar
  31. 31.
    Steinberg GD, Epstein JI, Piantados S, Walsh PC: Management of stage Dl adenocarcinoma of the prostate: The John Hopkins experience 1974–1987 J Urol 141:310A.Google Scholar
  32. 32.
    Rosenberg SJ, Loening SA, Hawtrey CE, Narayana AS, Culp DA: Radical prostatectomy with adjuvant radioactive gold for prostatic cancer: A preliminary report. J Urol 133: 225–227.Google Scholar
  33. 33.
    Gibbons RP, Cole BS, Richardson RG, Correa RJ Jr., Brannen GE, Mason JT, Taylor WJ, Hafermann MD: Adjuvant radiotherapy following radical prostatectomy: Results and complications. J Urol 135:65–68.Google Scholar
  34. 34.
    Bahnson RR, Garnett JE, Grayhack JT: Adjuvant radiation therapy in stages C and D1 prostatic adenocarcinoma: Preliminary results. Urology 27:403–406.Google Scholar
  35. 35.
    Ray GR, Bagshaw MA, Freiha F: External beam radiation salvage for residual or recurrent local tumor following radical prostatectomy. J Urol 132:926–930.Google Scholar
  36. 36.
    Jacobson GM, Smith JA Jr., Stewart JR: Postoperative radiation therapy for pathologic stage C prostate cancer. Int J Radiat Oncol Biol Phys 13:1021–1024.Google Scholar
  37. 37.
    Lange PH, Reddy PK, Medini E, Levitt S, Fraley EE: Radiation therapy as adjuvant treatment after radical prostatectomy. NCI Monogr 7:141–149.Google Scholar
  38. 38.
    Pilepich MV, Walz BJ, Baglan RJ: Postoperative irradiation in carcinoma of the prostate. Int J Radiat Oncol Biol Phys 10:1869–1873.Google Scholar
  39. 39.
    Forman JD, Wharam MB, Lee DJ, et al.: Definitive radiotherapy following prostatectomy: Results and complications. Int J Radiat Oncol Biol Phys 12:185–189.Google Scholar
  40. 40.
    Anscher MS, Prosnitz LR: Postoperative radiotherapy for patients with carcinoma of the prostate undergoing radical prostatectomy with positive surgical margins, seminal vesicle involvement and/or penetration through the capsule. J Urol 138:1407–1412.Google Scholar
  41. 41.
    Zincke H, Utz DC, Benson RC Jr., et al.: Bilateral pelvic lymphadenectomy and radical retropubic prostatectomy for stage C adenocarcinoma of prostate. Urology 24:532–539.Google Scholar
  42. 42.
    Smith JA Jr., Haynes TH, Middleton RG: Impact of external irradiation on local symptoms and survival free of disease in patients with pelvic lymph node metastasis from adenocarcinoma of the prostate. J Urol 131:705–707.Google Scholar
  43. 43.
    Link P, Freiha FS, Stamey TA: Adjuvant radiation therapy in patients with detectable prostatic specific antigen following radical prostatectomy. J Urol, in press.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Michael K. Brawer
    • 1
  1. 1.Department of UrologyUniversity of WashingtonSeattleUSA

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