Clinical significance of erbB2 protein overexpression

  • Soonmyoung Paik
  • Elizabeth Burkhard
  • Marc E. Lippman
Part of the Cancer Treatment and Research book series (CTAR, volume 61)


Originally described as a homologue of the EGF receptor gene amplified in breast cancer [1], erbB-2 protein is now thought to be a cell membrane receptor for a newly described ligand-gp30 [2]. There is some confusion in the literature about the terminology for erbB-2. In brief, erbB-2, c-erbB-2, and HER-2 refer to the same human gene residing in the long arm of the chromosome 17, which has homology to human EGF receptor gene (c-erbB) [3]. erbB-2 protein, p185erbB-2, or p185HER-2 refer to the transmembrane receptor protein translated from the erbB-2 gene, which has a molecular weight of 185 kDa. c-neu refers to the rat counterpart of the erbB-2 gene [4].


Breast Cancer Gastric Cancer Intraductal Component Cocktail Antibody Extracellular Ligand Binding Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Soonmyoung Paik
  • Elizabeth Burkhard
  • Marc E. Lippman

There are no affiliations available

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