Abstract
Two of the greatest problems in clinical oncology today are resistance of patients' tumors to chemotherapeutic agents and progression of patients' tumors with invasion and metastases. New approaches to both of these problems are certainly needed.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Watanable T: Infectious heredity of multiple drug resistance in bacteria. Bact Rev. 27:87–115, 1963.
Thomashow MF, Nutler R, Postle K et al: Recombination between higher plant DNA and the ti plasmid of agarobriterim tunefaciens. Proc. Nat. Acad. Sci. USA. 77:6448–6452, 1980.
Stark GR: DNA amplification in drug resistant cells and in tumors. Cancer Survey 5:1–23, 1986.
Alitalo K, Schwab M: Oncogenes amplification in tumor cells. Adv. Cancer Res. 47:235–281, 1985.
Carman MD, Schornagel IH, Ribert RS et al: Resistance to methotrexate due to gene amplification in a patient with acute leukemia. J. Clin. Oncol. 2:16–26, 1984.
Horns RC, Dower WI, Schimke RT: Gene amplification in a leukemia patient treated with methotrexate. J. Clin. Oncol. 2:2–7, 1984.
Trent I, Buick RN, Olson, S et al: Cytologic evidence for gene amplification in methotrexate resistant cells obtained from patients with ovarian adenocarcinomas. J. Clin. Oncol. 2:8–15, 1984.
Curt GA, Carney DN, Cowan KH et al: Unstable methotrexate resistance in human small cell carcinomas associated with double minute chromosomes. N. Engl. J. Med. 208:199–202, 1983.
Clark JL, Reizer SH, Mittelman A, Berger FG: Thymidylates synthase gene amplification in a color tumor resistant to fluoropyrimidine chemotherapy. Cancer Treat. Rep. 71:261–265, 1987.
Gerlach JH, Bell DR, KaraKonsis C et al: P-glycoprotein in human carcinomas: evidence for multidrug resistance. J. Clin. Oncol. 5:1452–1460, 1987.
Bell DR, Gerlach JH, Kartner N et al: Detection of P-glycoprotein in ovarian cancer: A molecular marker associated with multidrug resistance. J. Clin. Oncol. 3:311–315, 1985.
Seeger RC, Brodeur GM, Sather H et al: Association of multiple copies of the N-myc oncogene with rapid regression of neuroblastomas. N. Engl. J. Med. 313:1111–1116, 1985.
Slamon DJ, Clark GM, Wong FS et al: Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu-oncogene. Science 235:177–180, 1987.
Johnson BE, Batley J, Linnoila I et al: Changes in the phenotype of human small cell lung cancer cell lines alter transection and expression of the c-myc proto-oncogene. J. Clin. Invest. 78:525–532, 1986.
Wahl GM, de Saint Vincent R, De Rose ML: Effect of chromosomal position on amplification of transfected genes in animal cells. Nature 307:516–520, 1984.
Carroll SM, Gaudray P, De Rose ML et al: Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: Functional evidence for a mammalian replication origin. Mol. Cell Biol. 7:1740–1750, 1987.
Carroll GM, De Rose ML, Gaudray P et al: Early events in gene amplification: A chromosomal deletion produces submicroscopic precursors of double minutes. Mol. Cell Biol. 8:1525–1533, 1988.
Ruiz JC, Choi K, Von Hoff DD et al: Autonomously replicating episome-containing mdr-1 gene in a multidrug resistant human cell line. Mol. Cell. Biol. 9:109–115, 1989.
Mauer BJ, Lai E, Hamkalo BA et al: Novel submicroscopic extrachromosomal elements containing genes in human cells. Nature 327:434–437, 1987.
VanDevanter DR, Von Hoff DD: Episomal DNA formation during hydroxyureaphorbal ester mediated dhfr gene amplification. Submitted, 1990.
Garvey EP, Santi DV: Stable amplified DNA in drug-resistance Leisnmania exists as extrachromosomal circles. Science 253:535–540, 1986.
Von Hoff DD, Needham-VanDevanter DC, Yucel J et al: Amplified oncogenes are contained in replicating submicroscopic circular DNA molecules in human tumor cells. Proc. Natl. Acad. Sci. USA 85:4804–4808, 1988.
Von Hoff DD, Forseth BJ, Clare N et al: Double minutes arise from extrachromosomal DNA intermediates which integrate into chromosomal sites in HL60 leukemia cells. J. Clin. Invest. In press, 1990.
Gardella T, Medveczky P, Sairenji T, Mulder C: Detection of circular and linear herpes virus DNA molecules in mammalian cells by gel electrophoresis. J. Virol. 50:248–254, 1984.
Cosse F, Boucher C, Julliot JS et al: Identification and characterization of large plasmids in rhizobium meliloti using gel agarose electrophoresis. J. Gen. Microbiol. 113:229–242, 1979.
VanDevanter DR, Forseth BJ, Von Hoff DD: Optimal detection and further characterization of submicroscopic c-myc episomal DNA is HL60 cell. Submitted, 1990.
VanDevanter DR, Trammell HM, Von Hoff DD: Simple construction of rubber-based agarose block molds for pulsed-field electrophoresis. BioTechniques 7:143–144, 1989.
Carle GE, Frank M, Olson MV: Electrophoretic separations of large DNA molecules by periodic inversion of the electric field. Science 232:65–68, 1986.
Van der Bliek AM, Lincke CR, Borst P: Circular DNA of 3T6R50 double minute chromosomes. Nucleic Acids Res. 16:4841–4851, 1988.
VanDevanter DR, Piaskowski VD, Casper JT, Von Hoff DD: Amplified N-myc sequences can be located on circular extrachromosomal DNA molecules in primary and metastatic neuroblastomas. J. Nat. Cancer Inst. (in press) 1990.
Snapka RM, Varshavsky A: Loss of unstably amplified dihydrofolate reductase gene from mouse cells is greatly accelerated by hydroxyurea. Proc. Natl. Acad. Sci. USA 80:7533–7537, 1983.
Von Hoff DD, Eorseth B, Bradley T, Wahl G: Hydroxyurea can decrease oncogene copy number in human tumor cell lines. Proc. Am. Soc. Clin. Oncol. 9:55, 1990.
Von Hoff DD, VanDevanter D, Eorseth B et al: Hydroxyurea can decrease drug resistance gene copy numbers in tumor cell line. Proc. Am. Assoc. Cancer Res. In press, 1990.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Von Hoff, D.D. (1992). Extrachromosomal DNA as a Target for Drug Development. In: Valeriote, F.A., Corbett, T.H., Baker, L.H. (eds) Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development. Developments in Oncology, vol 68. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3492-1_13
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3492-1_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6548-8
Online ISBN: 978-1-4615-3492-1
eBook Packages: Springer Book Archive