Antitumor-Promoting Activities of Tannic Acid, Ellagic Acid, and Several Gallic Acid Derivatives in Mouse Skin

  • Jean-Pierre Perchellet
  • Hala U. Gali
  • Elisabeth M. Perchellet
  • Darren S. Klish
  • Andrew D. Armbrust
Part of the Basic Life Sciences book series (BLSC, volume 59)


Naturally occurring plant phenols with antimutagenic and anticarcinogenic activities were tested for their abilities to inhibit the biochemical and biological effects of the potent tumor promoter 12- O-tetradecanoylphorbol-13-acetate (TPA) in mouse epidermis in vivo. When applied topically to mouse skin, tannic acid (TA), ellagic acid, and several gallic acid derivatives all inhibit TPA-induced ornithine decarboxylase activity, hydroperoxide production, and DNA synthesis, three biochemical markers of skin tumor promotion. Moreover, in the two-step initiation-promotion protocol, the same phenolic compounds also inhibit the incidence and yield of skin tumors promoted by TPA. TA is the most effective of these treatments. Since they are already known to inhibit tumor initiation, the plant phenols protecting against skin tumor promotion by TPA may be universal inhibitors of multistage carcinogenesis. TA and other polyphenols, therefore, might be valuable in cancer therapy and/or prevention.


Ellagic Acid Benzoyl Peroxide Mouse Skin Skin Tumor Plant Phenol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Jean-Pierre Perchellet
    • 1
  • Hala U. Gali
    • 1
  • Elisabeth M. Perchellet
    • 1
  • Darren S. Klish
    • 1
  • Andrew D. Armbrust
    • 1
  1. 1.Anti-Cancer Drug LaboratoryKansas State UniversityManhattanUSA

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