Plant Polyphenolic Complex Inhibits The Reproduction of Influenza and Herpes Simplex Viruses

  • Julia Serkedjieva
  • Nadya Manolova
Part of the Basic Life Sciences book series (BLSC, volume 59)


A polyphenolic complex (PC), isolated from the Bulgarian medicinal plant Germanium sanguineum L., inhibited the reproduction of influenza virus types A and B in vitro and in ovo. It protected white mice in an experimental lethal influenza infection. When influenza viruses were treated with a high dose (1 mg/mL), their hemagglutination, neuraminidase and infections activities were reduced completely. It was assumed that the PC-specific inhibitory effect on influenza virus reproduction in tissue cultures (50 μ/mL) was mediated by partial inactivation of viral glycoproteins which prevented the initial stages of reproduction. The PC also affected the intracellular stages of viral replication. The effect was dependent on the mode of application, the viral strain, and the biological test system. The PC also inhibited the reproduction of herpes simplex virus in vitro. Infectious titers were reduced and newly synthesized virion with damaged protein envelopes were observed by electron microscopy.


Influenza Virus Antiviral Activity Vero Cell Antiviral Effect Viral Glycoprotein 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Julia Serkedjieva
    • 1
  • Nadya Manolova
    • 1
  1. 1.Institute of MicrobiologyBulgaria Academy of ScienceSofiaBulgaria

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