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Hamster Lung Cancer Model of Carcinogenesis and Chemoprevention

Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 320)

Abstract

Attempts to establish a lung cancer model in hamsters that is histologically and biochemically similar to bronchogenic carcinoma in man have had limited success (1,2). Earlier hamster and mouse studies employed methods such as thread transfixions (3, 4) and exposure to radioactive compounds either by inhalation (5) or implantation of intrabronchial pellets (6). Lung cancer models in hamsters employed by Saffiotti and his associates (7–10) required the intratracheal instillation of suspensions of a crystalline polycyclic aromatic hydrocarbon adsorbed to carrier particles of inert dust. The use of nitroso-compounds, with and without carrier dust, to induce tracheal and pulmonary lesions in hamsters has also been employed (11–15). However, the physiochemical properties of these carcinogens, such as solubility and particle size, and the nature of the carrier particles are very critical with regard to tumor induction. As a result, the feasibility of obtaining a reproducible incidence of respiratory cancer in different laboratories using these techniques appears remote. Furthermore, many of the earlier lung tumor models exhibited a very low cancer incidence and a long latency period.

Keywords

Bronchogenic Carcinoma Intratracheal Instillation Syrian Golden Hamster Carrier Particle Retinyl Palmitate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media New York 1992

Authors and Affiliations

  1. 1.Life Sciences ResearchIIT Research InstituteChicagoUSA
  2. 2.Chemoprevention BranchNational Cancer InstituteBethesdaUSA

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